解码儿科喉回流:通过多通道内阻抗和pH洞察解开症状
Ivan Pavić1,2, Petar Prcela2, Josip Pejić3
1Department of Pulmonology, Allergology and Immunology, Children's Hospital Zagreb, 10000 Zagreb, Croatia.
Diagnostics (Basel, Switzerland)
|January 11, 2025
概括
弱酸性反流在儿科喉回流 (LPR) 中起着重要作用,并与呼吸系统症状有关. 客观的监测对于诊断和管理儿童的LPR至关重要.
科学领域:
- 儿科胃肠病学 儿科胃肠病学
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 过敏和免疫学 过敏和免疫学
背景情况:
- 喉回流 (LPR) 症状与多通道内阻抗-pH (MII-pH) 监测的客观测量之间的相关性尚未得到充分证实.
- 了解这些关系对于准确诊断和有效管理儿科LPR至关重要.
研究的目的:
- 调查LPR症状与客观反流发作之间的关联.
- 探索光纤耳鼻喉检测结果,乙素细胞计数,血清IgE水平和MII-pH检测到的儿童反流发作之间的相关性.
主要方法:
- 一项前性研究,涉及113名疑似LPR的儿童.
- 使用MII-pH监测,光纤喉腔镜 (评估反流发现得分,RFS),鼻子擦拭剂以检测埃索诺菲尔,总血清IgE和反流症状指数 (RSI) 来评估症状.
主要成果:
- 在患有慢性咳和复发性支气管阻塞的儿童中,反流发作最为频繁.
- 在逆流发作和耳鼻喉检测结果之间发现了显著的正相关性 (鼻/耳鼻膜高血,耳鼻膜红血).
- 总体,酸性和弱酸性反流发作与RSI和RFS正相关. 靠近性逆流与鼻腔的埃索诺菲尔相关,但与血清IgE相反.
结论:
- 弱酸性反流与儿科LPR有很大关系,并与呼吸系统症状有关.
- 客观的监测技术对于LPR评估至关重要.
- 研究结果为改进儿科LPR的诊断和管理策略提供了见解.
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