非侵入性生物标志物和呼吸测试用于诊断和监测慢性肝病
Pasawat Boon-Yasidhi1, Wikrom Karnsakul2
1Department of Pharmacology, Faculty of Medicine, Chulalongkorn University, Bangkok 10330, Thailand.
Diagnostics (Basel, Switzerland)
|January 11, 2025
概括
非侵入性检测 (NIT) 为肝脏活检提供了一个有希望的替代方案,用于诊断和监测慢性肝病 (CLD). 结合各种NIT可以提高准确性和患者护理,转向可访问的肝病管理.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 诊断医学 诊断医学
- 生物标志物发现发现
背景情况:
- 慢性肝病 (CLD) 构成了全球卫生挑战,需要改进诊断和监测工具.
- 传统的标准肝脏活检有其局限性,包括侵入性和采样错误.
- 非侵入性测试 (NIT) 正在成为评估肝纤维化和疾病进展的关键替代方案.
研究的目的:
- 审查非侵入性测试 (NIT) 在评估慢性肝病严重性的有效性.
- 探索NIT在监测治疗反应和疾病进展中的作用.
- 突出新兴生物标志物和结合NIT战略的潜力.
主要方法:
- 对目前关于非侵入性CLD测试的文献的审查.
- 讨论了血清生物标志物面板 (FIB-4,APRI,ELF).
- 分析成像技术 (短暂弹性图像,磁共振弹性图像).
- 探索新的生物标志物 (细胞外囊泡,微RNA).
主要成果:
- 已建立的NIT和新兴生物标志物在纤维化阶段和早期检测方面显示出潜力.
- 组合NIT提高了诊断准确度,减少了侵入性活检的需要.
- 尼特促进肝脏健康的动态监测,使个性化的患者护理.
结论:
- 虽然存在标准化和成本等挑战,但NIT在临床实践中越来越多地被采用.
- 尼特代表着向可访问和非侵入性慢性肝病管理的范式转变.
- 为了改善患者的治疗结果和建立未来的护理标准,NIT的持续进步至关重要.
相关概念视频
Serum Laboratory Studies, Stool Test, Breath Test
311
Gastrointestinal (GI) diagnostic studies are pivotal in confirming, ruling out, diagnosing, or staging various diseases, including cancers. Following diagnosis, allocating time for discussions with the patient and providing informational resources is crucial. Diagnostic assessments of the GI tract often occur in outpatient settings like endoscopy suites or GI labs. Preparation for these tests may include dietary restrictions, fasting, liquid bowel preparations, laxatives, enemas, and the...
311
Ultrasound II: Endoscopic Ultrasound and FibroScan
76
Endoscopic Ultrasound (EUS) and FibroScan are valuable diagnostic tools in gastroenterology and hepatology, each with specific applications and techniques.
Endoscopic Ultrasound (EUS):
Endoscopic Ultrasound (EUS):
76
Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies
2.5K
Assessing and diagnosing Chronic Obstructive Pulmonary Disease (COPD) involves a detailed approach that includes a comprehensive review of medical history, physical examination, and a variety of diagnostic tests. This thorough evaluation is essential to ensure an accurate diagnosis and guide effective management strategies.
Medical History
Medical History
2.5K
Chronic Obstructive Pulmonary Disease-I: Introduction
2.8K
Chronic Obstructive Pulmonary Disease (COPD) is a long-lasting respiratory condition requiring continuous attention and care. It is a progressive lung disease that leads to breathing challenges due to airflow obstruction. It manifests as persistent respiratory symptoms and restricted airflow resulting from abnormalities in the airways and alveoli, usually due to long-term exposure to harmful particles or gases. COPD mainly consists of two primary conditions: emphysema and chronic bronchitis.
2.8K
Blood Studies for Cardiovascular System I: Cardiac Biomarkers
96
Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
96
Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
56
Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
56


