目前开发抗菌表面的策略,用于关节关节整形植入物应用
Giovana Collombaro Cardoso1, Diego Rafael Nespeque Correa1, Marco Fosca2
1Laboratório de Anelasticidade e Biomateriais, UNESP-Universidade Estadual Paulista, Bauru 17.033-360, SP, Brazil.
Materials (Basel, Switzerland)
|January 11, 2025
概括
假肢植入物的抗菌涂层提供了一种有前途的策略,用于对抗具有挑战性的假肢关节感染 (PJIs). 本综述分析了开发有效涂层以预防手术部位感染的方法.
科学领域:
- 生物材料科学 生物材料科学
- 传染性疾病 传染性疾病
- 整形外科手术 整形外科手术
背景情况:
- 假肢关节感染 (PJI) 影响1-2%的关节关节置换术,造成严重的死亡风险.
- 目前使用静脉注射抗生素的治疗方法往往对生物膜和组织结合的病原体无效.
- 迫切需要创新的策略来预防和治疗PJIs.
研究的目的:
- 审查开发用于假肢关节应用的抗菌涂层植入物的方法.
- 强调在体内测试的研究,以潜在的临床转化.
- 找出有希望的策略来减少与感染有关的手术失败.
主要方法:
- 对制造抗菌涂层的技术进行了全面的文献审查.
- 分析的重点是将抗微生物剂纳入植入物涂层的研究.
- 强调体内有效性和安全性数据.
主要成果:
- 不同的涂层技术显示出提供抗菌剂的潜力.
- 成功的涂层需要广泛的活性,低毒性,成本效益和骨愈合支持.
- 在体内研究对于验证临床适用性至关重要.
结论:
- 抗菌涂层的植入物在预防PJIs方面是一个有希望的进步.
- 进一步的研究和体内验证对于临床实施至关重要.
- 开发有效的涂层可以显著减少由于感染而导致的手术失败.
相关概念视频
Bacterial Signaling
31.5K
Bacterial signaling can occur within bacteria (intracellular) or between bacteria (intercellular). At times, a group of bacteria behaves like a community. To achieve this, they engage in quorum sensing, the perception of higher cell density that causes changes in gene expression. Quorum sensing involves both extracellular and intracellular signaling. The signaling cascade starts with a molecule called an autoinducer (AI). Individual bacteria produce AIs that move out of the bacterial cell...
31.5K
Surface Membrane Barriers
1.0K
The skin and mucous membranes serve as the primary line of defense against pathogens by providing both physical and chemical protection. These barriers are essential in preventing the entry and establishment of microbes, thereby maintaining the integrity of the host.
The outer layer of the skin, the epidermis, is a robust barrier comprising layers of closely packed keratinized cells. This dense arrangement prevents microbes from penetrating the body. The periodic shedding of epidermal cells...
The outer layer of the skin, the epidermis, is a robust barrier comprising layers of closely packed keratinized cells. This dense arrangement prevents microbes from penetrating the body. The periodic shedding of epidermal cells...
1.0K
Hand hygiene
3.1K
Asepsis is the practice of preventing or breaking the chain of infection. The nurse employs aseptic techniques to prevent the spread of microorganisms and reduce the risk of diseases. Hand hygiene is the cornerstone of aseptic techniques and is classified into medical and surgical asepsis. Medical asepsis includes hand hygiene and the use of gloves. Surgical asepsis, or the sterile technique, refers to practices that render and keep objects and areas free of microorganisms.
Hand washing...
Hand washing...
3.1K


