运动训练对糖尿病心脏中心脏线粒体功能的影响:系统性审查
Iqbal Ali Shah1, Shahid Ishaq1, Shin-Da Lee1,2
1PhD Program in Healthcare Science, China Medical University, Taichung 40402, Taiwan.
International journal of molecular sciences
|January 11, 2025
概括
运动训练通过改善线粒体功能,有益于糖尿病患者的心脏. 定期体育活动可以增强心脏氧化酸化,生物发生和动力学,这对于管理糖尿病并发症至关重要.
科学领域:
- 心血管研究研究心血管研究
- 线粒体生物学 线粒体生物学
- 运动生理学 运动生理学
背景情况:
- 糖尿病心脏病包括纤维化,自,氧化应激和线粒体功能受损.
- 线粒体功能障碍是糖尿病心肌病的关键因素.
- 了解运动对心脏线粒体的影响对于治疗策略至关重要.
研究的目的:
- 审查运动训练对糖尿病心脏中心脏线粒体功能的影响.
- 综合关于运动如何影响线粒体氧化酸化,生物发生和动态的证据.
- 评估研究对糖尿病心脏线粒体进行运动干预的研究质量.
主要方法:
- 在PubMed,EMBASE和Web of Science的系统文献搜索 (2023年9月 - 2024年4月).
- 包括与运动训练 (≥3周) 报告对糖尿病人心脏功能影响的研究.
- 使用CAMARADES检查清单进行质量评估;包括10项研究 (得分为4-7/10).
主要成果:
- 运动训练通过减少活性氧物种 (ROS),促进电子运输链活动和增加ATP生产,改善了心脏线粒体的氧化酸化.
- 运动改善了线粒体生物发生,由AMPK,PGC-1α,Akt,Irisin和Sirtuin-III的水平增加表明.
- 运动训练对线粒体动力学产生了积极的影响,降低了裂变因子,并改善了线粒体的大小,潜力和透性.
结论:
- 运动训练在糖尿病心脏中对心脏线粒体功能产生显著的有益影响.
- 定期的体力活动可以增强关键的线粒体过程,包括氧化酸化,生物发生和动态.
- 运动是通过线粒体改善缓解糖尿病心肌病的有希望的非药物干预措施.
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