乳酸的抗氧化潜力及其对健康的保护作用:概述
Quintín Rascón-Cruz1, Tania Samanta Siqueiros-Cendón1, Luis Ignacio Siañez-Estrada1
1Laboratorio de Biotecnología I, Facultad de Ciencias Químicas, Universidad Autónoma de Chihuahua, Circuito Universitarios s/n Nuevo Campus Universitario, Chihuahua 31125, Mexico.
International journal of molecular sciences
|January 11, 2025
概括
乳酸 (Lf) 通过减少氧化应激和炎症来对抗慢性疾病. 这种糖蛋白调节铁,增强抗氧化防御,并提供神经保护,显示广泛的治疗潜力.
科学领域:
- 生物化学 生物化学
- 分子生物学分子生物学
- 病理学 病理学 病理学
背景情况:
- 癌症和神经退行性疾病等慢性疾病对全球健康构成挑战.
- 氧化应激,反应性氧物种 (ROS) 的不平衡,推动了疾病的进展.
- 乳酸 (Lf) 是一种结合铁的葡萄糖蛋白,具有抗氧化,抗炎和铁调节的特性.
研究的目的:
- 审查通过乳酸铁素减轻氧化应激的机制.
- 突出乳酸在慢性疾病中的治疗潜力.
主要方法:
- 关于乳酸铁素在氧化应激和慢性疾病中的作用研究的文献综述.
- 分析乳酸的铁结合,抗氧化,抗炎和神经保护性质.
- 检查乳酸对内源性抗氧化剂系统的影响.
主要成果:
- 乳二酸铁,减少ROS的产生,并调节细胞的铁吸收,从而减少氧化应激.
- 在帕金森氏症和阿尔茨海默氏症的模型中,乳酸显示出神经保护作用.
- 乳酸增强了抗氧化酶,如超氧化脱氧化酶和谷氨过氧化酶,提供全身保护.
结论:
- 乳酸是一种有前途的治疗剂,用于管理与氧化压力相关的慢性疾病.
- 它的多方面的特性,包括抗氧化和抗炎作用,强调了它的多功能性.
- 乳酸在铁稳定和神经保护中的作用需要进一步的临床研究.
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