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在内耳输送金纳米颗粒后,耳机械被保存

Dorothy W Pan¹, Jinkyung Kim^2,3, Patricia M Quiñones¹

¹Caruso Department of Otolaryngology-Head and Neck Surgery, University of Southern California, Los Angeles, CA 90033, USA.

International journal of molecular sciences

|January 11, 2025

概括

后半圆通道 (PSCC) 输液成功地将金纳米粒子输送到内耳,而没有改变耳机械. 这验证了PSCC输液作为内耳治疗输送的安全方法.

科学领域:

耳鼻喉科耳鼻喉科耳鼻喉科
纳米医学是一种纳米医学.
生物医学工程生物医学工程

背景情况:

内耳疾病和听力损失需要新的治疗传递系统.
内耳独特的解剖学为药物输送带来了重大障碍.
纳米粒子为有针对性的治疗提供了潜力.

研究的目的:

评估后半圆通道 (PSCC) 输注的可行性,以便将金纳米颗粒 (NP) 输送到尾.
为了评估NP在尾细胞内的分布.
为了确定PSCC输液对耳机械学的影响.

主要方法:

光学连贯断层扫描 (OCT) 用于监测输注过程和NP分布.
通过OCT振动计测量了声音引起的基底膜运动,以评估耳机械.
黄金纳米颗粒被输入到通过PSCC通道静脉切开术的临淋巴空间.

主要成果:

海外国家和地区证实,PSCC输液准确地准了尾细胞的周淋巴空间.
输注后没有观察到耳机械的显著变化.
基底膜运动在基线时保持不变,在运河切除术后,在NP输液后.

结论:

PSCC输液是一种验证的方法,用于将纳米粒子系统输送到耳周淋巴空间.
这种技术在治疗内耳疾病方面表现有前途.
输入PSCC可以保持现有的耳功能,使其成为一种潜在的安全治疗方法.

关键词:

耳机械学耳机械内耳药物输送药物输送到内耳纳米颗粒是一种纳米粒子.光学连贯性断层扫描技术

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相关概念视频

The Cochlea

The Cochlea

The cochlea is a coiled structure in the inner ear that contains hair cells—the sensory receptors of the auditory system. Sound waves are transmitted to the cochlea by small bones attached to the eardrum called the ossicles, which vibrate the oval window that leads to the inner ear. This causes fluid in the chambers of the cochlea to move, vibrating the basilar membrane.

Hearing

Hearing

When we hear a sound, our nervous system is detecting sound waves—pressure waves of mechanical energy traveling through a medium. The frequency of the wave is perceived as pitch, while the amplitude is perceived as loudness.