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类风湿性关节炎和其他类风湿性疾病患者之间的唾液细胞因子和病原体负荷的差异

Aleksandra Korzeniowska¹, Agnieszka Daca¹, Maria Szarecka²

¹Department of Physiopathology, Faculty of Medicine, Medical University of Gdansk, 80-210 Gdansk, Poland.

International journal of molecular sciences

|January 11, 2025

概括

类风湿性关节炎 (RA) 患者表现出唾液中细胞因子的变化以及爱斯坦-巴尔病毒 (EBV) 和 Porphyromonas gingivalis 的较高水平. 这些发现表明,感染可能在RA的发病过程中发挥作用,并突出突出唾液.

科学领域:

免疫学免疫学免疫学
微生物学微生物学
类风湿病学类风湿病学

背景情况:

类风湿性关节炎 (RA) 是一种自身免疫性疾病,其特征是免疫失衡和改变的细胞因子配置.
口腔失生症和感染与慢性疾病有关,可能与RA的发病因子有关.
唾液中的细胞因子和微生物剂可以作为RA的生物标志物.

研究的目的:

与健康对照和其他类风湿性疾病相比,研究RA患者的唾液细胞因子概况.
评估RA患者的唾液中特定的病毒和细菌DNA的存在.
探索唾液生物标志物与RA潜在传染病原体之间的关联.

主要方法:

从RA患者,健康对照者和患有其他类风湿性疾病的患者收集唾液样本.
使用流细胞计测量测量了细胞因子水平.
使用qRT-PCR量化了爱斯坦-巴尔病毒 (EBV),细胞巨乳病毒,帕尔沃病毒B19, Porphyromonas gingivalis 和Segatella copri的DNA水平.

主要成果:

在RA患者的唾液中,IL-1β,IP-10,IL-2和IL-4的水平显著升高.
在RA患者中,EBV和P. gingivalis的唾液DNA水平显著更高.
特定的细胞因子概况与某些病毒和细菌感染的存在相关.

结论:

唾液分析显示了RA患者的明显的细胞因子概况,表明了潜在的诊断价值.
在RA唾液中EBV和P. gingivalisDNA的升高表明在疾病发病或增加易感性方面发挥了作用.
了解感染和免疫反应之间的相互作用对于理解RA复杂性至关重要.

关键词:

爱斯坦·巴尔病毒葡萄牙牙牙病 Porphyromonas gingivalis 这种虫害的细胞因子细胞因子病变的发生和发病.类风湿性关节炎类风湿性关节炎

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