抵抗训练对卵巢切除的老鼠血液动力学和脏线粒体生物能量功能的预防性影响
Anne L F Queiroz1,2, Christopher B Garcia1, João P M O Silva3
1Department of Physiological Sciences, Interinstitutional Post-Graduate Program of Physiological Sciences, Federal University of São Carlos (UFSCar), São Carlos 13.566-490, SP, Brazil.
International journal of molecular sciences
|January 11, 2025
概括
更年期引起的雌激素下降会损害脏线粒体功能,并提高血压. 抵抗训练通过改善线粒体生物能学和脏中的基因表达来抵消这些影响.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學.
- 内分泌学 在内分泌学.
- 运动生理学 运动生理学
背景情况:
- 更年期的特点是雌激素耗尽,增加患慢性病 (CKD) 和动脉高血压 (AH) 等疾病的风险.
- 在动物模型中,卵巢切除 (OVX) 模仿更年期诱导的低雌激素,可能导致脏线粒体功能障碍.
- 运动训练在管理成年人的CKD和AH方面显示出前景.
研究的目的:
- 研究OVX和抵抗训练 (RT) 对脏血液动力学参数和线粒体生物能功能的影响.
- 评估RT对与线粒体功能相关的基因表达的影响,在低雌激素的背景下.
主要方法:
- 雌性Wistar大鼠被分配到卵巢切除 (OVX) 或完整 (INT) 组,并且要么保持久坐状态 (SED),要么接受13周的RT.
- 血液动力学参数是使用尾部囊造影测量.
- 通过高分辨率呼吸计评估线粒体呼吸功能,并使用qPCR分析基因表达 (电子输送链[ETC]和氧化酸化[OXPHOS]).
主要成果:
- OVX-SED小鼠表现出显著升高的静脉缩和平均动脉压,以及脏线粒体生物能学受损.
- 与它们的静止对应物相比,RT在INT和OVX大鼠中改善了线粒体的生物能量功能.
- OVX减少了线粒体ETC和OXPHOS的基因表达;RT阻止了这种减少,并提高了这些基因的调节.
结论:
- 由于OVX的低雌激素性显著损害了脏线粒体的氧化酸化和静止动物的电子运输链能力.
- 抵抗训练通过增强线粒体基因表达和脏功能来有效地抵消低雌激素的负面影响.
- RT可能是一个可行的策略,以减轻与更年期和相关条件,如高血压相关的功能障碍.
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