精神分裂症中的神经炎症循环,与症状或认知能力下降有联系吗?
Claudio Carril Pardo1, Karina Oyarce Merino1, América Vera-Montecinos2
1Laboratorio de Neuroinmunología, Facultad de Medicina y Ciencia, Universidad San Sebastián, Sede Tres Pascualas, Concepción 4080871, Chile.
International journal of molecular sciences
|January 11, 2025
概括
炎症和互白蛋白的失衡可能导致精神分裂症的认知能力下降. 针对这种免疫失衡可能为精神分裂症患者提供新的治疗策略.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 免疫学 免疫学 免疫学
背景情况:
- 精神分裂症 (SZ) 是一种带有认知恶化的神经发育障碍.
- 假设炎症事件有助于SZ症状和认知能力下降.
- 炎症分子在SZ相关认知障碍中的确切作用尚不清楚.
研究的目的:
- 审查介素失衡对精神分裂症认知障碍的贡献.
- 探索炎症对SZ中的微质细胞,星球细胞和血脑屏障 (BBB) 的影响.
- 讨论肠道微生物群,炎症和中枢神经系统对SZ的影响之间的联系.
主要方法:
- 文献综述总结了有关炎症和SZ的当前研究.
- 分析促炎和抗炎互白蛋白 (例如IL-1β,IL-4,TNF-α) 的作用.
- 讨论对质细胞 (微细胞,星球细胞) 和BBB的影响.
主要成果:
- 亲炎性和抗炎性互白蛋白之间的不平衡与认知缺陷有关.
- 神经炎症会影响小质细胞和星球细胞,可能会破坏BBB并影响认知功能.
- 肠道微生物群的变化和抗精神病药物的使用可以影响中枢神经系统的炎症.
结论:
- 炎症分子失衡显著导致精神分裂症的认知障碍.
- 调节炎症失衡为SZ提供了潜在的治疗途径.
- 免疫调节策略可以补充传统治疗方法,特别是在疾病早期阶段.
相关概念视频
Negative and Cognitive Symptoms of Schizophrenia
43
Negative symptoms of schizophrenia indicate a reduction or absence of typical behaviors and emotional responses found in healthy individuals, while positive symptoms reflect an excess or distortion of normal functioning.
Negative Symptoms
Negative symptoms of schizophrenia manifest as deficits in normal emotional and behavioral functioning, profoundly impacting daily life. Individuals with schizophrenia often display a flat affect, characterized by a near-total absence of emotional expression,...
Negative Symptoms
Negative symptoms of schizophrenia manifest as deficits in normal emotional and behavioral functioning, profoundly impacting daily life. Individuals with schizophrenia often display a flat affect, characterized by a near-total absence of emotional expression,...
43
Psychological and Sociocultural Causes of Schizophrenia
54
Schizophrenia, a complex psychiatric disorder, has been historically misunderstood. Early psychological theories attributed its origins to childhood trauma and unresponsive parenting. However, contemporary research largely rejects these notions, favoring the vulnerability-stress hypothesis. This model proposes that individuals with a genetic predisposition to schizophrenia may develop the disorder following exposure to significant environmental stressors. Notably, studies on high-risk...
54
Biological Causes of Schizophrenia
42
Schizophrenia, a severe psychiatric disorder, arises from a complex interplay of biological factors, including genetic predisposition, structural brain abnormalities, neurotransmitter dysregulation, and developmental irregularities. These factors collectively contribute to the onset and progression of the disorder, which typically manifests in late adolescence or early adulthood.
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin...
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin...
42
Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders
427
Schizophrenia is a neurodevelopmental disorder whose origins are rooted in complex genetic components. Despite our burgeoning understanding, the pathophysiology of this disorder remains incompletely deciphered.
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within...
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within...
427
Neural Regulation
39.1K
Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.
39.1K
Schizophrenia
66
Schizophrenia, a term introduced by Swiss psychiatrist Eugen Bleuler in 1911, describes a severe psychological disorder marked by profound disruptions in attention, thought processes, language, emotion, and interpersonal relationships. The core feature of schizophrenia is psychosis — a state characterized by a fundamental detachment from reality. This disconnection manifests through distorted logic, impaired perception, and atypical behavior, severely affecting the lives of those...
66


