身体炼:对抗器官纤维化的一种有希望的治疗方法
Xiaojie Ma1, Bing Liu1, Ziming Jiang1
1College of Physical Education, Shanghai University, Shanghai 200444, China.
International journal of molecular sciences
|January 11, 2025
概括
定期运动通过减少炎症和调节关键分子通路来对抗器官纤维化. 这篇评论探讨了炼运动.
科学领域:
- 病理学 病理学 病理学
- 生理学 生理学 生理学
- 分子生物学分子生物学
背景情况:
- 纤维化是慢性疾病的病理标志,其特点是炎症,纤维细胞激活和过度的细胞外基质沉积.
- 器官纤维化会影响肝脏,心脏,肺部,脏和肌肉等重要器官,并具有既定的病理机制.
- 定期运动提供健康益处,包括抗炎,抗氧化和抗衰老作用.
研究的目的:
- 为了审查运动的抗纤维性作用.
- 阐明运动在改善器官纤维化中的作用背后的分子机制.
主要方法:
- 对研究运动和纤维化病的文献综述.
- 通过与纤维化相关的运动调节的分子通路的分析.
- 检查运动对炎症和纤维化过程的影响.
主要成果:
- 运动通过影响多个信号通路来表现出抗纤维性质.
- 运动调节的关键通路包括TGF-β1/Smad,Wnt/β-catenin,NF-kB和ROS.
- 运动会影响微RNA表达 (miR-126,miR-29a,miR-101a) 和具有抗纤维素作用的运动激素 (FGF21,素,FSTL1,CHI3L1).
结论:
- 运动是一个有希望的,非药物干预器官纤维化.
- 了解运动介导的分子机制可以指导治疗纤维化症的治疗策略.
- 对运动的抗纤维性潜力的进一步研究是有必要的.
相关概念视频
Exercise and Cardiovascular Response
727
Exercise significantly impacts cardiovascular response, which is crucial for understanding patient health and designing effective treatment plans.
Light to moderate physical activity initiates a series of interconnected responses in the body. The heart rate modestly increases in anticipation of the workout, followed by widespread vasodilation as oxygen consumption by skeletal muscles increases. This results in decreased peripheral resistance, increased capillary blood flow, and accelerated...
Light to moderate physical activity initiates a series of interconnected responses in the body. The heart rate modestly increases in anticipation of the workout, followed by widespread vasodilation as oxygen consumption by skeletal muscles increases. This results in decreased peripheral resistance, increased capillary blood flow, and accelerated...
727
Exercise and Muscle Performance
1.3K
Exercise induces a range of adaptations in muscle tissue, depending on the type and duration of activity. Such physical training can be broadly categorized into two types: endurance exercises and resistance exercises.
Endurance exercises
Endurance exercises involve running, swimming, or cycling, which require repetitive movements with low force output. When a person engages in endurance exercise, a few noticeable changes occur in their skeletal muscles. For instance, the number of capillaries...
Endurance exercises
Endurance exercises involve running, swimming, or cycling, which require repetitive movements with low force output. When a person engages in endurance exercise, a few noticeable changes occur in their skeletal muscles. For instance, the number of capillaries...
1.3K
Exercise and Cardiac Output
908
Regular physical activity is essential for maintaining cardiovascular health, with aerobic exercises being particularly effective. According to the American Heart Association, 150 minutes of moderate to intense aerobic exercise per week is recommended for a healthy heart. Aerobic activities may include brisk walking, running, bicycling, cross-country skiing, and swimming, ideally performed three to five times per week.
Sustained exercise increases the muscles' oxygen demand, which can be...
Sustained exercise increases the muscles' oxygen demand, which can be...
908
Liver Regeneration
3.2K
The liver is an important organ in vertebrates that plays an essential role in metabolism. It is also responsible for storing and redistributing nutrients such as carbohydrates, fats, and vitamins in the body. Additionally, the liver releases bile salts which are critical for digesting food and eliminating toxic metabolites from the body.
Cells of Liver
The liver comprises four major types of cells— hepatocytes, stellate, Kupffer, and sinusoidal endothelial cells. The hepatocytes are...
Cells of Liver
The liver comprises four major types of cells— hepatocytes, stellate, Kupffer, and sinusoidal endothelial cells. The hepatocytes are...
3.2K


