抗癌植物二次代谢物从染色体中驱逐链接组合基因素H1.2 激活I型干扰素信号传递

Olga Vlasova1, Irina Antonova1, Khamis Magomedova1

  • 1N. N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia, 24 Kashirskoe Shosse, 115522 Moscow, Russia.

概括

某些抗癌植物化合物可以通过去除链接基因素,激活I型干扰素信号传递和有时LINE1表达来破坏染色质的稳定性. 这揭示了一种新的机制,将染色质变化与免疫反应联系起来.

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