卵泡液和胚胎质量中的氧化恒温 - 一项试点研究
Ana Jeremic1, Mladenko Vasiljevic1,2, Zeljko Mikovic1,2
1University Clinic for Gynecology and Obstetrics "Narodni Front", 11000 Belgrade, Serbia.
International journal of molecular sciences
|January 11, 2025
概括
卵泡液中较低的氧化应激和抗氧化酶活性与更好的胚胎质量和体外受精结果有关. 这项研究测量了氧化还原生物标志物,以评估它们对胚胎发育的影响.
科学领域:
- 生殖生物学 生殖生物学
- 生物化学 生化学
- 不孕症的研究研究.
背景情况:
- 氧化应激对生殖健康和胚胎发育起着重要作用.
- 毛囊液中的Redox生物标志物可能表明胚胎质量.
研究的目的:
- 测量毛囊液中的氧化还原生物标志物水平.
- 使用一个卵泡-一个卵细胞/胚胎方法,将这些水平与胚胎质量相关联.
- 评估对体外受精 (IVF) 结果的影响.
主要方法:
- 对54名接受试管婴儿的妇女进行前性研究.
- 毛囊液生物标志物的分析,包括抗氧化酶 (超氧化脱酶,谷氨过氧化酶,谷氨转移酶) 和氧化应激标志物 (马隆迪甲,8-氧-2'-脱氧氨酸,醇组).
- 生物标志物水平与胚胎质量的相关性 (I-IV级).
主要成果:
- 与I级胚胎相比,在质量较低的胚胎 (II-IV级) 中发现了抗氧化酶的显著更高的活动.
- 在低质量的胚胎中观察到氧化应激标志物度显著增加.
- 在氧化标志物和抗氧化酶活性之间发现了显著的正相关性 (p < 0.001).
结论:
- 卵泡液中低水平的氧化应激和低抗氧化酶活性与高质量的胚胎有关.
- 这些发现表明,卵泡环境中的氧化还原平衡对于成功的试管婴儿结果至关重要.
相关概念视频
Oogenesis
63.4K
In human women, oogenesis produces one mature egg cell or ovum for every precursor cell that enters meiosis. This process differs in two unique ways from the equivalent procedure of spermatogenesis in males. First, meiotic divisions during oogenesis are asymmetric, meaning that a large oocyte (containing most of the cytoplasm) and minor polar body are produced as a result of meiosis I, and again following meiosis II. Since only oocytes will go on to form embryos if fertilized, this unequal...
63.4K
Folliculogenesis
582
Folliculogenesis is the development of ovarian follicles, the specialized structures within the ovarian cortex where oogenesis, or egg development, occurs. This process is essential for female reproductive health and begins during fetal development when primordial follicles are formed. Each primordial follicle comprises a primary oocyte in the center, surrounded by a single layer of squamous pre-granulosa cells. These follicles remain dormant in late prophase I of meiosis until triggered by...
582
Hormonal Control of the Ovarian Cycle
404
The ovarian cycle is meticulously regulated by the hypothalamic-pituitary-gonadal axis. This cycle orchestrates the release of a mature oocyte, essential for reproduction.
Before puberty, the hypothalamus releases GnRH in a low frequency, low amplitude pulsatile manner. This along with the immature hypothalamic-pituitary-gonadal axis activity, results in low estrogen levels and the absence of a fully functional ovarian cycle. At puberty, GnRH secretion increases in both frequency and...
Before puberty, the hypothalamus releases GnRH in a low frequency, low amplitude pulsatile manner. This along with the immature hypothalamic-pituitary-gonadal axis activity, results in low estrogen levels and the absence of a fully functional ovarian cycle. At puberty, GnRH secretion increases in both frequency and...
404
Ovarian Cycle
982
The menstrual cycle includes a critical component known as the ovarian cycle, which undergoes two main phases each month—the follicular phase and the luteal phase. The follicular phase is variable and averaging around 14 days. Ovulation, triggered by a surge in luteinizing hormone (LH), marks the transition between the two phases. The second phase, the luteal phase, is relatively consistent, lasting approximately 14 days, and is marked by the activity of the corpus luteum. While a cycle...
982


