阿克尔曼西亚:预防糖尿病的潜在目标
Kairu He1,2,3, Feiyu An1,2,3, Henan Zhang1,2,3
1College of Food Science, Shenyang Agricultural University, Shenyang 110866, China.
Foods (Basel, Switzerland)
|January 11, 2025
概括
肠道细菌Akkermansia muciniphila在治疗糖尿病方面显示出潜在的潜力. 研究审查了其成分和干预措施,以恢复其丰富的治疗效益.
科学领域:
- 微生物学 微生物学
- 代谢性疾病是一种代谢性疾病.
- 益生菌研究的研究.
背景情况:
- Akkermansia muciniphila是一种与代谢健康相关的肠道细菌.
- 在A. muciniphila的丰富性中出现的干扰与糖尿病及其并发症有关.
研究的目的:
- 系统地审查A. muciniphila在糖尿病中的机制.
- 探索基于A. muciniphila的糖尿病治疗方法,包括活性成分和干预措施.
- 突出使用A. muciniphila治疗的潜力和挑战.
主要方法:
- 文献综述和现有研究的系统摘要.
- 对A. muciniphila成分的分析:Amuc_1100,AmEVs,P9和Amuc_1409. 这三种组分.
- 检查影响A. muciniphila丰度的饮食和药理干预措施.
主要成果:
- A. muciniphila及其成分表现出与糖尿病相关的各种作用机制.
- 几个干预措施,包括饮食和药理,可以调节A. muciniphila水平.
- 识别特定的A. muciniphila活性成分,以潜在的治疗用途.
结论:
- A. muciniphila有望成为糖尿病管理的下一代益生菌.
- 需要进一步的研究来开发基于A. muciniphila的疗法和治疗点.
- 这一综述可以作为未来关于A. muciniphila和糖尿病的研究的参考.
相关概念视频
Oral Hypoglycemic Agents: α-Glucosidase Inhibitors
152
α-glucosidase inhibitors, including acarbose (Precose), miglitol (Glyset), and voglibose (Voglib) (primarily available in Asia), are drugs that control blood sugar levels by delaying the digestion of starch and disaccharides. They achieve this by inhibiting α-glucosidase enzymes in the intestine, which slow the absorption of carbohydrates in the intestine, which in turn leads to a prolonged release of the glucoregulatory hormone GLP-1 from intestinal L-cells.
Acarbose and miglitol are...
Acarbose and miglitol are...
152
Glucagon-like Receptor Agonists
295
Incretins include glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP), which stimulate insulin secretion post-meals. In type 2 diabetes, GIP's efficacy is reduced, making GLP-1 a viable drug target. GIP originates from preproGIP.
GLP-1, when administered in high doses intravenously, triggers insulin secretion, inhibits glucagon release, slows gastric emptying, reduces food intake, and restores normal insulin secretion. However, its rapid inactivation by...
GLP-1, when administered in high doses intravenously, triggers insulin secretion, inhibits glucagon release, slows gastric emptying, reduces food intake, and restores normal insulin secretion. However, its rapid inactivation by...
295
Oral Hypoglycemic Agents: Biguanides and Glitazones
165
Biguanides, particularly metformin (Glucophage), are insulin sensitizers that enhance glucose uptake, thereby reducing insulin resistance. Unlike sulfonylureas, metformin doesn't prompt insulin secretion, which helps to curb hypoglycemia risk. Metformin is beneficial in treating conditions like polycystic ovary syndrome due to its insulin-resistance reduction capability. The drug's primary action involves curtailing hepatic gluconeogenesis, a significant contributor to high blood...
165
Dipeptidyl Peptidase 4 Inhibitors
166
Dipeptidyl peptidase 4 (DPP-4) is a serine protease widely distributed in the body. It's involved in the inactivation of GLP-1 and GIP hormones, which are crucial for insulin regulation. DPP-4 inhibitors, such as sitagliptin (Januvia), saxagliptin (Onglyza), linagliptin (Tradjenta), alogliptin (Nesina), and vildagliptin (Galvus), help increase the proportion of active GLP-1, enhancing insulin secretion. These inhibitors work by competitively binding to DPP-4. This binding causes a...
166
Diabetes: Management and Pharmacotherapy
233
The therapy for diabetes aims to alleviate hyperglycemia-related symptoms, prevent acute metabolic decompensation, and reduce chronic end-organ complications. Glycemic control is evaluated through short-term (self-monitoring, continuous glucose monitoring) and long-term (A1c, fructosamine) metrics, enabling near real-time tracking of blood glucose levels and reflecting glycemic control over specific time frames.
Insulin remains the cornerstone of treatment for most patients with type 1 and many...
Insulin remains the cornerstone of treatment for most patients with type 1 and many...
233


