替代性禁食和限时食对胎盘功能和胎儿发育在孕产妇肥胖症中的比较影响
Siyuan Liu1,2, Lun Hua1,2, Xi Mo1,2
1Animal Nutrition Institute, Sichuan Agricultural University, Chengdu 611130, China.
Nutrients
|January 11, 2025
概括
时间限制养 (TRF) 在高脂肪饮食 (HFD) 的肥胖小鼠中改善了胎盘功能和胎儿发育. 替代性禁食 (ADF) 恶化了胎盘压力和胎儿生长限制.
科学领域:
- 生殖生物学 生殖生物学
- 营养科学 营养科学
- 孕产妇和胎儿的医学
背景情况:
- 孕产妇肥胖会对胎盘功能和胎儿发育产生负面影响.
- 替代性禁食 (ADF) 和限时食 (TRF) 是具有潜在代谢益处的饮食干预措施.
- 对ADF和TRF对胎盘功能和胎儿发育的比较影响尚不清楚.
研究的目的:
- 为了研究ADF和TRF对胎盘功能和胎儿发育的影响,在母亲高脂肪饮食 (HFD) 消费的背景下.
- 为了比较ADF和TRF在减轻怀孕期间HFD诱导的代谢障碍方面的疗效.
主要方法:
- 100只雌性小鼠被分为四组:正常饮食 (NA),自由自在的HFD (HA),ADF的HFD (HI) 和TRF的HFD (HT).
- 在怀孕前和怀孕期间进行了饮食干预.
- 产妇和胎儿血清和胎盘样本在妊娠18.5天被收集用于分析.
主要成果:
- 在怀孕的小鼠中,ADF和TRF都减轻了HFD诱导的代谢障碍.
- TRF增强了胎盘的营养物质运输和胎儿发育,减少了内质网膜 (ER) 的压力和炎症.
- ADF加剧了胎盘的压力和炎症,损害了营养物质的运输,并导致胎儿的生长受限.
结论:
- 饮食干预措施,特别是TRF,可以积极影响肥胖孕妇小鼠的胎盘功能和胎儿发育.
- TRF显示出对HFD诱导的胎盘功能障碍和不良胎儿结果的保护作用.
- 然而,ADF似乎有害,加剧胎盘压力,导致胎儿生长受限.
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