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对于下尿道症状的男性,Salvia miltiorrhiza根提取物:一个多中心,随机,双盲,安慰剂控制的试验
Dongho Shin1, Hyong Woo Moon1, Woong Jin Bae1
1Department of Urology, College of Medicine, The Catholic University of Korea, Seoul 06591, Republic of Korea.
Nutrients
|January 11, 2025
概括
在12周内,Salvia miltiorrhiza根提取物 (SAGX) 有效地改善了男性的下泌尿道症状 (LUTS) 和勃起功能. 与传统治疗相比,这种天然化合物表现出了有利的安全性.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 自然产品研究自然产品研究
- 男人的健康 男人的健康
背景情况:
- 下尿道症状 (LUTS) 在老年男性中很常见.
- 自然化合物为LUTS管理提供了潜在的潜力,副作用较少.
- 萨尔维亚多草根提取物 (SAGX) 显示出对LUTSs的临床前前景.
研究的目的:
- 评估SAGX在患有LUTSs的男性中的疗效和安全性.
- 评估SAGX对尿路症状和勃起功能的影响.
- 在12周内,将SAGX (400mg和800mg) 与安慰剂进行比较.
主要方法:
- 多中心,随机,双盲,安慰剂对照试验.
- 136名男性受试者每天接受SAGX (400mg或800mg) 或安慰剂.
- 主要结局:国际前列腺症状评分 (IPSS) 的变化. 二次结局:PSA,丸激素,尿液流量,残留体积,IIEF.
主要成果:
- 两种SAGX剂量都显著改善了IPSS得分与安慰剂相比.
- 在不完全排空,频率,紧迫性,夜尿和生活质量方面发现了改善.
- 勃起功能 (IIEF) 显著改善,特别是在400mg的SAGX.
- 在PSA或丸激素水平上没有显著的变化.
- SAGX显示出良好的安全性,没有严重的不良事件.
结论:
- SAGX是一种有效和安全的治疗方法,可以改善男性的LUTS.
- 与传统疗法相比,SAGX可以增强勃起功能,副作用较少.
- 这种天然提取物为治疗男性下尿道症状提供了一个有希望的替代品.
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