葡萄种子提取物中氨酸对良性前列腺增生症的影响
Fortuna Iannuzzo1, Elisabetta Schiano2, Maria Maisto3
1Department of Pharmacy, University of Chieti-Pescara G. D'Annunzio, 66100 Chieti, Italy.
Nutrients
|January 11, 2025
概括
性加工葡萄种子提取物 (ATGSE) 在良性前列腺增生 (BPH) 动物模型中有效降低前列腺和精液囊的大小和PSA水平. 与标准葡萄种子提取物 (GSE) 相比,ATGSE在BPH治疗中显示出更高的疗效.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 自然产品 化学 化学
- 药理学 药理学是指药理学的学科.
背景情况:
- 良性前列腺增生 (BPH) 是40岁以上男性的常见病症.
- 益阳西亚尼丁 (PAC) 显示出治疗前列腺健康问题的潜力.
- 葡萄种子提取物 (GSE) 富含PAC,具有潜在的治疗应用.
研究的目的:
- 在BPH的动物模型中比较GSE和性加工的GSE (ATGSE) 的生物活性.
- 评估在ATGSE中对BPH的寡合PACs的疗效.
- 评估GSE和ATGSE对前列腺和精液囊健康的影响.
主要方法:
- 使用丸激素注射诱导BPH的动物模型.
- 动物通过口腔 gavage 接受了不同剂量的 GSE 和 ATGSE 的治疗.
- 在4周后进行了血液学,生化和组织分析.
主要成果:
- 与GSE相比,ATGSE显著降低了前列腺和精液囊的体重,比GSE更有效.
- ATGSE在降低前列腺特异性抗原 (PSA) 水平方面表现出卓越的疗效.
- 在前列腺和精液囊中,ATGSE显著降低了促炎性细胞化学因子.
结论:
- 而ATGSE对于BPH来说是一个比GSE更强大的治疗剂.
- 作为BPH管理的营养或功能性食品,ATGSE显示出承诺.
- 对于前列腺健康,ATGSE的进一步临床应用是有必要的.
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