在袖子胃切除术两年后,青少年的代谢适应及其决定因素
Vibha Singhal1,2,3,4, Clarissa C Pedreira1,4, Shubhangi Tuli2
1Division of Pediatric Endocrinology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
Nutrients
|January 11, 2025
概括
青少年的袖子胃切除术 (SG) 导致显著的体重减轻和减少休息能量消耗 (REE),但在两年后没有代谢适应. 手术后的新陈代谢会得到稳定,这使得无偏见的体重管理策略成为可能.
科学领域:
- 代谢和腹部手术 代谢和腹部手术
- 儿科内分泌学 儿科内分泌学
- 肥胖医学 肥胖医学
背景情况:
- 减肥干预措施,包括袖子胃切除术 (SG),由于身体组成的变化,可以改变休息能量消耗 (REE).
- 有限的数据存在测量REE (mREE) 和代谢适应性在SG后青少年.
研究的目的:
- 为了评估mREE的变化,代谢适应和身体组成在SG后的青少年与非手术 (NS) 控制相比,在两年内.
主要方法:
- 招募的青少年 (14-22岁) 接受了严重肥胖的SG (n=24) 和NS对照 (n=28).
- 通过间接热度计量测量REE (mREE) 并计算预测的REE (pREE) 来评估代谢适应 (mREE - pREE).
- 在基线和两年随访时使用双能X射线吸收计评估身体组成.
主要成果:
- 与NS对照组相比,SG组显示出显著更大的BMI减少和mREE的减少.
- 虽然mREE正常化为无脂肪质量 (FFM) 在SG组内下降,但mREE/FFM和mREE/TBW的两年变化在各组之间没有差异.
- 在两年后,在SG组中没有观察到显著的代谢适应.
结论:
- 接受SG的青少年经历了显著的体重减轻和REE降低,但他们的新陈代谢似乎在手术后两年达到稳定状态.
- 缺乏代谢适应表明,两年后的体重变化应该在没有与代谢补偿相关的偏差的情况下进行管理.
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