老年人肠道微生物群,肌肉质量和身体功能之间的关系:系统性审查
David J Barry1, Sam S X Wu1, Matthew B Cooke1,2
1School of Health Sciences, Swinburne University of Technology, Melbourne VIC 3122, Australia.
Nutrients
|January 11, 2025
概括
肠道微生物群影响老年人肉类的发展和肌肉健康. 针对肠道微生物群的干预措施显示了对治疗肉症和改善身体功能的潜力.
科学领域:
- 老年学是一门学科.
- 微生物学 微生物学
- 营养科学 营养科学
背景情况:
- 标志着肌肉质量和功能下降的萨科佩尼亚越来越多地与通过微生物群-肠-肌肉轴的肠道微生物群变化有关.
- 有限的研究已经系统地探索了肠道微生物群在肉症中的作用,以及饮食干预对老年人肌肉健康的影响.
研究的目的:
- 系统地审查老年人肠道微生物群,肌肉质量和身体表现之间的关系.
- 评估肠道调节饮食干预措施对老年人肉症相关结果的影响.
主要方法:
- 在四个数据库 (PubMed,MEDLINE,Embase,Scopus) 进行了系统的文献搜索,搜索了2004年至2023年7月期间发表的研究.
- 遵循了系统审查和元分析 (PRISMA) 的首选报告项目指南.
- 偏差风险使用修订的Cochrane偏差风险 (RoB 2.0) 和Joanna Briggs Institute (JBI) 批判性评估工具进行了评估.
主要成果:
- 包括20项研究 (14项观察性,6项干预性) 与4071名老年参与者,显示了方法和结果的显著异质性.
- 在肠道微生物群多样性/组成和与肉症相关的功能结果之间存在观察到的相关性.
- 针对肠道微生物群的干预措施产生了混合的结果,一些研究表明肌肉力量,身体组成或身体功能得到改善.
结论:
- 有证据表明,改变肠道微生物环境有助于萨科佩尼亚的发展.
- 旨在调节肠道微生物群的干预措施可能为萨科佩尼亚治疗和管理提供治疗潜力.
- 需要进一步的研究来澄清微生物群-肠-肌肉轴内的复杂相互作用,并优化干预措施.
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