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β-基酸盐通过通过AMPK/Nrf2通路抑制内分泌网膜压力介导的亡,缓解动脉样结石

Yu Chen¹, Yiran You¹, Xin Wang¹

¹Department of Nutrition, School of Public Health, Sun Yat-Sen University, Guangzhou 510080, China.

|January 11, 2025

概括

β-基酸盐 (BHB) 通过抑制内细胞网膜应激 (ERS) 介导的亡,减少动脉样硬化化 (AC). 这表明BHB可能是AC的潜在治疗方法.

科学领域:

心血管研究研究心血管研究
代谢性疾病代谢性疾病
细胞生物学细胞生物学

背景情况:

动脉样硬化化 (AC) 是心血管疾病的一个标志.
β-基酸盐 (BHB) 影响心血管健康,但其对心血管健康的影响尚不清楚.

研究的目的:

调查BHB对动脉样硬化化的影响.
探索BHB对AC采取行动的潜在机制.

主要方法:

利用西方饮食的ApoE-/-小鼠和老鼠血管光滑肌细胞 (VSMC).
服用BHB补充剂并分析了大动脉化,含量和性酸酶 (ALP) 活性.
评估GRP78和CHOP的表达,以评估细胞内膜网膜应激 (ERS) 和亡.

主要成果:

在小鼠中,BHB补充剂降低了大动脉化,含量和ALP活性.
BHB降低了GRP78和CHOP的调节,减轻了小鼠大动脉中的ERS和亡.
在体外,BHB抑制了VSMC化,降低了ALP活性,并抑制了ERS介导的亡.

结论:

BHB通过抑制ERS介导的亡来缓解动脉样硬化化.
BHB显示出作为动脉样硬化化的治疗剂的潜力.

关键词:

灭症 (apoptosis) 是一种死亡的过程.动脉样硬化的化.细胞内膜网膜的压力应激这是β-Hydroxybutyrate.

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