通过独家母乳养来保护婴儿免受冠状病毒感染:一项跨部门研究
Yasmin Amaral1,2, Antonio Egidio Nardi3, Daniele Marano2
1Postdoctoral Program-Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro (FAPERJ), Rio de Janeiro 21941-909, Brazil.
Nutrients
|January 11, 2025
概括
接种SARS-CoV-2 (COVID-19) 疫苗会诱导母乳中对Omicron变种的中和抗体,无论疫苗类型如何. 纯母乳养进一步增强了牛奶中的这些保护性抗体.
科学领域:
- 免疫学 免疫学 免疫学
- 公共卫生 公共卫生
- 儿科 儿科 儿科
背景情况:
- 针对SARS-CoV-2 (COVID-19) 的母体疫苗接种对于婴儿的保护至关重要.
- 了解不同疫苗技术对母乳抗体水平的影响至关重要.
- 欧米克朗变种对疫苗诱导的免疫提出了独特的挑战.
研究的目的:
- 为了确定SARS-CoV-2疫苗接种后人乳中对Omicron变异的中和抗体的存在和持续时间.
- 为了比较在巴西使用的不同疫苗技术 (AstraZeneca,Pfizer,CoronaVac,Janssen) 中的抗体诱导.
- 评估疫苗剂量和母乳养对抗体水平的影响.
主要方法:
- 涉及里约热内卢哺乳妇女的横截面研究 (2022年4月至10月).
- 对母乳样本进行针对Omicron特异性中和抗体的分析.
- 基于疫苗类型,剂量数和母乳养实践的抗体水平的比较.
主要成果:
- 所有疫苗类型都有效地诱导了母乳中的中和抗体来对抗Omicron变种.
- 在两剂或三剂疫苗之间没有观察到抗体水平的显著差异.
- 纯母乳养与母乳中中和抗体的百分比较高显著相关.
结论:
- 母亲的SARS-CoV-2疫苗接种有助于通过母乳促进婴儿的被动免疫力.
- 哺乳是为为婴儿提供防治呼吸道病毒的重要策略.
- 这些发现支持母乳养,特别是当婴儿接种疫苗尚未推时.
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