对于自体主导多囊性脏病的基因干预的治疗潜力:系统性审查
Donglai Li1,2, Jessica Dawson3,4, Jenny E Gunton1,2,5
1Centre for Diabetes, Obesity and Endocrinology Research (CDOER), Westmead Institute for Medical Research, Westmead, Sydney, NSW 2145, Australia.
Nutrients
|January 11, 2025
概括
性饮食对自体主导多囊性病 (ADPKD) 是有前途的,通过减缓疾病进展和改善动物模型中的功能. 人类研究表明,减肥和血压改善等潜在益处,尽管需要更大规模的试验.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 代谢障碍 代谢障碍 代谢障碍
- 营养科学 营养科学
背景情况:
- 自体主导多囊性病 (ADPKD) 的特征是细胞能量代谢异常.
- 营养症正在成为ADPKD的潜在治疗策略.
- 性干预可能有助于减缓或逆转ADPKD的进展.
研究的目的:
- 系统地审查和综合现有的关于ADPKD的基干预措施的文献.
- 评估性饮食和β-基酸盐补充剂对ADPKD的影响.
- 评估在ADPKD管理中的性方法的有效性,坚持性和安全性.
主要方法:
- 在Medline,Embase和Scopus数据库中进行系统的文献搜索.
- 包括在ADPKD的人类和动物模型中对基因干预的研究.
- 数据提取和分析与疾病进展,功能和安全相关的结果.
主要成果:
- 性饮食 (KD) 在大鼠中减缓了PKD的进展,改善了功能,减少了囊大小,纤维化和细胞增殖.
- 在老鼠中补充β-基酸盐 (BHB) 显示了剂量依赖的PKD进展的减少.
- 人类研究 (n=129) 显示,KD导致体重减轻 (∼4公斤),血压改善,对估计的淋巴细胞过率 (eGFR) 有好处.
- 虽然体积结果是混合的,但脂质资料显示总和LDL胆固醇的增加. 安全性问题包括"基托流感"和尿酸升高.
结论:
- 目前针对ADPKD的性饮食的人类研究是有希望的,但受到小样本大小和短时间的限制.
- 需要进行更大规模的长期临床试验,以确定在ADPKD患者中代饮食的疗效,坚持和安全性.
- 需要进行进一步的研究,以优化ADPKD管理的性策略.
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