在不同时间点进行负载后葡萄糖的比较,以确定MASLD进展的高风险
Long Teng1, Ling Luo1, Yanhong Sun2
1Department of Gastroenterology, The First Affiliated Hospital, Sun Yat-sen University, No. 58 Zhongshan II Road, Yuexiu District, Guangzhou 510080, China.
Nutrients
|January 11, 2025
概括
监测1小时后的葡萄糖 (1hPG) 水平对于识别代谢功能障碍相关的脂肪性肝病 (MASLD) 和相关并发症,如肝损伤和动脉样硬化,至关重要. 这凸显了1hPG在临床查和管理中的重要性.
科学领域:
- 代谢综合征是代谢综合征的一种.
- 肝病学 肝病学是一种肝病学.
- 心血管疾病 心血管疾病
背景情况:
- 1小时后负载血葡萄糖 (1hPG) 测试被提议作为糖尿病前期/糖尿病的替代诊断标准.
- 它在识别渐进的代谢功能障碍相关脂肪性肝病 (MASLD) 的有效性需要进一步调查.
研究的目的:
- 评估1hPG与2小时后葡萄糖 (2hPG) 相比在识别MASLD时的优势.
- 评估1hPG和2hPG与亚洲参与者的肝硬化,纤维化,损伤和动脉样硬化的相关性.
主要方法:
- 在2012年6月至2024年6月期间,有2214名亚洲参与者 (1049名非MASLD,1165名MASLD) 的回顾性招生.
- 通过CT扫描量化肝脏肥胖症;使用血清标志物评估肝脏纤维化.
- 统计分析包括赔率比率 (OR) 和接收器运行特征 (ROC) 曲线分析.
主要成果:
- 在MASLD患者中,升高的1hPG水平与中度至重度的肝肥胖症显著相关 (OR=2.19).
- 升高的1hPG和2hPG都与肝损伤 (OR=2.03) 和动脉样硬化 (OR=2.77对1hPG,OR=2.98对2hPG) 的风险增加有关.
- 升高的2hPG水平与肝纤维化有关 (OR=1.99-2.72).
结论:
- 该研究强调了监测1hPG水平的临床必要性,以查和管理MASLD.
- 1hPG在识别MASLD和相关的代谢并发症,包括肝损伤和动脉样硬化方面具有实用性.
- 这些发现支持将1hPG监测纳入MASLD患者的临床实践.
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