维生素D补充剂在严重不良叙述审查中
Lenko Saric1,2, Josipa Domazet Bugarin1, Svjetlana Dosenovic1
1Department of Anesthesiology, Reanimatology and Intensive Care, University Hospital Split, 21000 Split, Croatia.
Nutrients
|January 11, 2025
概括
维生素D缺乏症在重症患者中很常见. 这次审查发现,维生素D补充剂没有显著影响死亡率或在重症监护病房 (ICU) 停留的时间.
科学领域:
- 关键护理医学 关键护理医学
- 营养科学 营养科学
- 临床研究 临床研究
背景情况:
- 维生素D缺乏症在重症患者中很普遍,与肺炎,败血症和死亡率的风险增加有关.
- 现有的关于这种人群中维生素D补充剂的研究显示了多样化的结果.
- 这篇叙述性综述综合了在重症患者中补充维生素D的随机对照试验 (RCT) 的证据.
研究的目的:
- 审查和总结来自RCT的关于维生素D补充在重症患者的疗效的证据.
- 确定目前关于维生素D在重症监护中的研究趋势和局限性.
主要方法:
- 通过PubMed在MEDLINE中对符合条件的RCT进行了全面的文献搜索.
- 系统性审查和元分析的参考文献被选,正在进行的研究在clinicaltrials.gov.gov上进行了搜索.
- 包括标准是广泛的,没有对维生素D剂量,服用途径或结果的限制.
主要成果:
- 分析了21个涉及3166名患者的RCT,揭示了患者特征和试验设计的显著异质性.
- 只有少数研究集中在确诊的维生素D水平低于50nmol/L的患者身上.
- 大多数研究发现,维生素D干预和对照组之间死亡率,重症监护室 (ICU) 停留时间 (LoS) 或医院LoS没有显著差异.
结论:
- 在试验设计中存在显著的变化,包括患者选择,维生素D剂量和给药方案.
- 标准化方案和基线维生素D水平的测量对于未来的临床研究至关重要.
- 改善研究设计是必要的,以准确评估维生素D补充剂在重症患者群体中的影响.
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