复发性鼻皮状细胞癌:当前见解和治疗进展
Meryl B Kravitz1,2, Vivek Annadata3, Benjamin Ilyaev3
1Department of Otolaryngology/Head & Neck Surgery, Zucker School of Medicine, Hofstra University, New York, NY 11040, USA.
Cancers
|January 11, 2025
概括
复发性鼻腔状细胞癌 (SNSCC) 影响了近一半的患者. 救援手术是主要的持久治疗方法,当手术不可能时,化学辐射作为替代方案.
科学领域:
- 在瘤学瘤学.
- 头部和部手术 头部和部手术
背景情况:
- 状细胞癌 (SCC) 是最常见的鼻道恶性瘤.
- 局部复发是初级鼻腔SCC (SNSCC) 的频繁治疗失败,影响近50%的患者.
- 由于稀有性和多样化的做法,对于管理复发性SNSCC (rSNSCC) 存在有限的指导方针.
研究的目的:
- 审查关于复发性SNSCC (rSNSCC) 的病因学,病理生理学,诊断,预后因素和治疗的当前证据.
- 为了解决这一具有挑战性的瘤疾病的管理提供了洞察力.
主要方法:
- 关于复发性鼻腔状细胞癌现有证据的文献综述.
- 对诊断标准,预后指标和治疗策略的分析.
主要成果:
- 挽救手术目前是符合条件的RSNSCC患者最持久的治疗选择.
- 由于先前的手术或放射治疗,重建通常是必要的.
- 化学辐射作为辅助或息选择,当手术是不可行的.
结论:
- 治疗复发性鼻SCC需要仔细考虑治疗史和患者的资格.
- 救援手术,通常是复杂的重建,为持久的结果提供了最好的机会.
- 目前正在进行的免疫疗法和颗粒疗法的研究可能会为未来的治疗途径提供机会.
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