超越烧伤:在甲状腺癌的放射性废除疗法后,白血病的威胁
Mohammad H Hussein1,2, Eman Toraih1, Jessan A Jishu3
1Division of Endocrine and Oncologic Surgery, Department of Surgery, School of Medicine, Tulane University, New Orleans, LA 70112, USA.
Cancers
|January 11, 2025
概括
对差异化甲状腺癌 (DTC) 的放射性 (RAI) 治疗显著增加白血病风险,特别是在年轻患者和某些种族群体中. 需要进一步的研究来理解这些关联.
科学领域:
- 在瘤学瘤学.
- 血液学 血液学 血液学
- 流行病学 流行病学
背景情况:
- 差异化甲状腺癌 (DTC) 通常用放射性 (RAI) 废除疗法治疗.
- 虽然已知RAI与固体癌症的联系,但其与白血病风险的关联不太清楚.
- 这项研究探讨了在DTC患者中RAI和白血病之间的研究不足的联系.
研究的目的:
- 在RAI治疗后对DTC患者的白血病及其亚型的差异风险进行调查.
- 在DTC幸存者中,量化RAI治疗与非RAI治疗相关的白血病风险.
主要方法:
- 从监测,流行病学和最终结果 (SEER) 注册表17 (2000-2019) 中对差异化甲状腺癌 (DTC) 患者的分析.
- 计算标准发病率比率 (SIR) 和过度风险 (ER) 以比较DTC患者的白血病发病率与一般人群.
- 风险分层根据治疗组 (RAI与非RAI),诊断时的年龄和种族/民族.
主要成果:
- 白血病是DTC治疗后最常见的血液恶性瘤 (SIR 1.74).
- 与非RAI治疗 (SIR 1.45) 相比,RAI治疗显著增加了白血病风险 (SIR 2.12).
- 在年轻患者 (<55岁,SIR 2.74) 和美国印第安人/阿拉斯加原住民幸存者 (SIR 7.63) 中观察到较高风险.
结论:
- 作为DTC患者的辅助治疗,RAI治疗增加了患白血病的风险.
- 在DTC患者的RAI治疗和随后的白血病发病率之间存在显著的关联.
- 在RAI治疗后的白血病风险受到年龄,性别,诊断后的时间和种族背景的影响.
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