抗生素与癌症治疗的协同作用潜力
Giuseppe Nardo1, Pan Pantziarka2,3, Matteo Conti4
1Fondazione IRCCS Istituto Nazionale dei Tumori, Via Venezian 1, 20133 Milano, Italy.
Cancers
|January 11, 2025
概括
抗生素可以改变瘤内微生物群 (瘤内的微生物),以增强癌症治疗. 向居住在瘤中的细菌可能会改善化疗,向治疗和免疫治疗的有效性.
科学领域:
- 在瘤学瘤学.
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
背景情况:
- 内微生物群,瘤内的微生物,与肠道微生物群不同.
- 这些微生物影响瘤生物学,癌症进展和治疗反应.
- 新兴的研究探索调节内微生物群以获得治疗效益.
研究的目的:
- 审查关于使用抗生素调节内微生物群的临床前证据.
- 探索抗生素和常规癌症疗法之间的协同作用.
- 讨论向内细菌的潜在临床影响.
主要方法:
- 对研究抗生素-化疗,抗生素向治疗和抗生素-免疫疗法组合的临床前研究的分析.
- 检查内细菌影响癌症进展和免疫逃避的机制.
- 综述了通过微生物群调节证明增强治疗功效的研究.
主要成果:
- 抗生素可以改变内微生物群的组成,影响癌症的进展.
- 一些内细菌促进免疫抑制和治疗耐药性.
- 用抗生素向这些细菌可以提高化疗,向治疗和免疫治疗的疗效.
结论:
- 用抗生素调节内微生物群,有望改善癌症治疗结果.
- 抗生素干预可以克服由瘤相关微生物介导的治疗耐药性.
- 涉及抗生素和其他癌症治疗的组合策略需要进一步的临床研究.
相关概念视频
Combined Effects of Drugs: Synergism
3.7K
Synergism is a useful mechanism where combining two or more drugs is more effective than each constituent used alone. Such combinations are also called supra-additive interactions. The drugs collectively enhance the final therapeutic effect by acting on different targets. Another advantage is that the low dose of each constituent drug is sufficient to achieve the desired effect. This helps reduce the duration of therapy and lower the adverse effects of these drugs.
Such synergistic combinations...
Such synergistic combinations...
3.7K
Combination Therapies and Personalized Medicine
4.8K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
4.8K
Cancer Therapies
7.5K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
7.5K
Targeted Cancer Therapies
7.4K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.4K
Tumor Immunotherapy
472
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
472
Treatment Resistant Cancers
3.2K
Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
3.2K


