肠道失调症对肠道癌症发病的影响
Seema Kumari1, Mundla Srilatha2, Ganji Purnachandra Nagaraju3
1Cancer Biology Laboratory, Department of Biochemistry and Bioinformatics, GIS, GITAM (Deemed to Be University), Visakhapatnam 530045, Andhra Pradesh, India.
Cancers
|January 11, 2025
概括
肠道微生物群失生症通过改变免疫和代谢功能驱动胃肠癌. 像便微生物群移植 (FMT) 和益生菌这样的策略为肠道癌提供了潜在的治疗益处.
科学领域:
- 胃肠道学和瘤学
- 微生物组研究 微生物组研究
- 免疫学 免疫学 免疫学
背景情况:
- 肠道微生物群失调是胃肠道 (GI) 癌症发展的关键因素.
- 失生症影响免疫功能,新陈代谢,并通过各种途径促进致癌.
- 诸如*Helicobacter pylori*感染,基因毒素,生活方式和饮食等因素也会导致胃肠道癌.
研究的目的:
- 审查肠道微生物群在肠道癌症发病和进展中的作用.
- 探索胃肠道癌的新兴诊断和治疗策略.
- 讨论干预措施的潜力,如便微生物群移植 (FMT),益生菌和益生菌.
主要方法:
- 在PubMed,Scopus和Web of Science数据库中进行全面的文献搜索.
- 审查和综合有关肠道失调和肠道癌症的现有研究.
- 分析当前和新兴的诊断和治疗方法.
主要成果:
- 失生症通过免疫失调,新陈代谢改变和致癌代谢物导致肠胃癌.
- 改变的新陈代谢,遗传不稳定性和促炎信号与癌症的发展有关.
- 新兴的治疗方法,如多目标便免疫化学测试 (mtFIT) 和FMT与PD-1抑制剂相结合,对结直肠癌有望.
结论:
- 肠道失调是肠道癌症发展和进展的重要驱动因素.
- 便微生物种移植 (FMT),益生菌和益生菌是调节癌症治疗肠道微生物群的有希望的策略.
- 通过微生物组调节增强免疫反应和改善癌症治疗结果是未来研究的关键领域.
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