慢性淋巴细胞白血病护理及其他方面:满足长期幸存者的需求
Stefano Molica1, David Allsup1,2
1Department of Hematology, Hull University Teaching Hospitals NHS Trust, Hull HU3 2JZ, UK.
Cancers
|January 11, 2025
概括
向治疗已经将慢性淋巴细胞白血病 (CLL) 转变为可管理的疾病. 长期幸存者现在需要整体护理来治疗感染,心血管风险和二次癌症,以改善生活质量.
科学领域:
- 血液学 血液学 血液学
- 在瘤学瘤学.
- 老年病的医生 老年病的医生
背景情况:
- 慢性淋巴细胞白血病 (CLL) 治疗从化疗演变为向治疗,如布鲁顿氨酸激酶 (BTK) 和BCL-2抑制剂.
- 改善的生存率已经将重点转移到CLL幸存者的长期挑战上,包括感染,心血管问题和二次癌症.
- 主要影响老年人的CLL,往往有脆弱性和并发症影响治疗和生活质量 (QoL).
研究的目的:
- 强调在慢性淋巴细胞白血病 (CLL) 管理中需要整体护理模式.
- 强调将CLL治疗与脆弱性,并发性疾病和心理社会福祉的积极管理相结合.
- 探索综合老年医学评估和患者报告结果在优化CLL生存率方面的作用.
主要方法:
- 审查当前的治疗模式和慢性淋巴细胞白血病 (CLL) 存活率的新兴挑战.
- 讨论综合老年学评估 (GA) 对于识别风险患者的有用性.
- 强调将患者报告的结果 (PRO) 和虚弱度指标与血液学反应评估一起纳入.
主要成果:
- 向疗法显著提高了CLL患者的生存率,将疾病转化为慢性,可管理的疾病.
- 长期的CLL幸存者面临感染,心血管并发症和二次恶性瘤的风险增加.
- 老年人的评估和PRO提供了对治疗效益和患者幸福感的更全面的了解.
结论:
- 整体的,多学科的护理模式对于管理长期风险和提高CLL幸存者的生活质量 (QoL) 是必不可少的.
- 综合老年评估 (GA) 对于指导治疗选择和缓解患有CLL的脆弱老年人中毒性至关重要.
- 综合长期健康维护的以生存为重点的方法对于改善CLL患者的整体福祉至关重要.
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