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从细胞相互作用到床边实践:在静脉血栓栓塞中具有诊断和预后潜力的全血计衍生生物标志物

Emma Eugenia Murariu-Gligor^1,2, Simona Mureșan², Ovidiu Simion Cotoi^3,4

¹Doctoral School of Medicine and Pharmacy, George Emil Palade University of Medicine, Pharmacy, Science, and Technology of Targu Mures, 540142 Targu Mures, Romania.

Journal of clinical medicine

|January 11, 2025

概括

完全血清 (CBC) 衍生的免疫炎症指数,如中性粒细胞与淋巴细胞比率 (NLR),显示为可预测静脉血栓栓塞 (VTE) 风险和指导个性化管理策略的可访问生物标志物.

科学领域:

血液学血液学血液学
免疫学免疫学免疫学
血管生物学血管生物学

背景情况:

静脉血栓塞栓症 (VTE) 是一个重大的全球健康和经济挑战.
有效的VTE管理需要先进的诊断和风险分层工具.
新型生物标志物对于个性化的VTE治疗策略至关重要.

研究的目的:

审查用于个性化VTE管理的新型生物标志物.
探索免疫血栓和血栓炎症在静脉瘤病理生理学中的作用.
总结关于全血细胞计 (CBC) 衍生指数作为VTE生物标志物的研究.

主要方法:

对VTE病理生理学和生物标志物研究的文献综述.
分析全血清 (CBC) 衍生的免疫-炎症指数.
在血栓形成中的中性粒细胞和血小板相互作用的研究.

主要成果:

完全血清 (CBC) 衍生指数,包括中性粒细胞与淋巴细胞的比率 (NLR),血小板与淋巴细胞的比率 (PLR) 和全身免疫炎症指数 (SII),显示出血栓栓塞事件的预测价值.
这些指数反映了亲血栓状况,并且很容易获得.
目前关于临床应用的特定切断值的数据需要进一步调查.

结论:

来自CBC的免疫-炎症指数是对VTE风险评估有希望的,可访问的生物标志物.
需要进一步的研究来确定这些指数的临床切断值.
这些生物标志物可以通过反映免疫血栓形成和血栓炎症来增强个性化的VTE管理.

关键词:

深静脉血栓形成的原因是深静脉血栓形成.中性粒细胞与淋巴细胞的比率.血小板与淋巴细胞的比率.肺栓塞肺栓塞是一种肺栓塞.系统性免疫炎症指数静脉血栓塞栓症是一种静脉血栓塞栓.

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