达沙替尼和奎尔丁可以限制牙衰老,炎症和骨质损失
K Rattanaprukskul1,2, X-J Xia1, M Hysa1
1Department of Periodontics, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Journal of dental research
|January 11, 2025
概括
达沙替尼和奎尔丁 (DQ) 减少了牙周组织中的细胞衰老和炎症. 这种老年治疗方法改善了牙健康,减少了老年小鼠的骨损失,为牙周病提供了新的策略.
科学领域:
- 老年学和牙周学.
- 细胞衰老和衰老研究研究
- 在口腔健康中微生物群与宿主相互作用
背景情况:
- 细胞衰老是衰老的关键标志,也是包括牙周病在内的慢性疾病的驱动因素.
- 衰老细胞及其分泌因子 (SASP) 有助于牙周病原发生.
- 像达沙替尼和奎尔丁 (DQ) 这样的老年治疗药物,准老年细胞以改善健康.
研究的目的:
- 调查达沙替尼和奎尔丁 (DQ) 在缓解牙周组织衰老和SASP方面的疗效.
- 在临床前的老化和细菌挑战模型中评估DQ对牙周健康的影响.
主要方法:
- 在体外:暴露于*Fusobacterium nucleatum*的人类牙角质细胞被用DQ治疗.
- 评估了衰老标志物 (p16,SA-β-银酸酶,拉米尼-B1) 和SASP因子 (IL-8,MMP-1,MMP-3).
- 在体内:老年小鼠接受口服DQ,以评估对牙衰老,SASP和牙周骨损失的影响.
主要成果:
- DQ治疗减少了牙周细菌挑战的牙角质细胞中的衰老标志物和SASP因子.
- 口服DQ降低了老年小鼠的牙组织中的衰老细胞负担和SASP.
- 在老年小鼠中,DQ治疗显著降低了自然进展的牙周骨损失.
结论:
- 用DQ准牙衰老和与衰老相关的分泌体是改善牙周健康的可行策略.
- DQ证明了作为与年龄相关的牙周病和骨质损失的老年治疗干预的潜力.
- 这些发现支持在易受伤害的群体中对DQ进行进一步的翻译研究,这些群体面临牙周病的风险.
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