DisGeNet:一种以疾病为中心的疾病和各种相关基因之间的相互作用数据库
Yaxuan Hu1, Xingli Guo1, Yao Yun1
1School of Computer Science and Technology, Xidian University, 266 Xinglong Section of Xifeng Road, Xi'an, Shaanxi 710126, China.
Database : the journal of biological databases and curation
|January 11, 2025
概括
DisGeNet将基因与疾病的关联和相互作用,包括非编码RNA (ncRNA),整合到一个以疾病为中心的网络中. 这种全面的数据库通过揭示复杂的分子关系来增强对复杂疾病病原学的理解.
科学领域:
- 基因组学就是基因组学.
- 生物信息学是一种生物信息学.
- 网络医学 网络医学
背景情况:
- 复杂疾病的发病包括复杂的基因网络.
- 当前的数据库经常忽视非编码RNA (ncRNA) 相互作用.
- 现有的资源主要集中在基因与疾病的关联上,忽视了基因与基因的相互作用.
研究的目的:
- 开发DisGeNet,一个综合基因疾病关联和相互作用的综合数据库.
- 将非编码RNA (ncRNA) 纳入网络医学方法中.
- 创建一个以疾病为中心的分子相互作用的网络视图.
主要方法:
- 综合基因-疾病关联和基因-基因相互作用.
- 纳入了关于长非编码RNA (lncRNA) 和微RNA (miRNA) 的数据.
- 开发了一个以疾病为中心的网络结构,用于数据可视化.
主要成果:
- 在DisGeNet中存储了5,029,688个互动/关联.
- 数据库包括6,697种疾病,5,780个lncRNAs,16,135个蛋白质编码基因和2,610个miRNAs.
- 相互作用包括蛋白质-蛋白质,ncRNA-疾病,miRNA-基因,miRNA-疾病,基因-疾病和miRNA-lncRNA关系.
结论:
- DisGeNet提供了一个统一的资源,用于探索复杂的疾病网络.
- 该数据库有助于研究ncRNA在疾病发病过程中的作用.
- 用户可以通过网络视图搜索和可视化基因和疾病相互作用.
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