在美国成年人中,瘦肉代谢功能障碍相关的脂肪性肝病的当前负担,2017-2023年
Donghee Kim1, Pojsakorn Danpanichkul2, Karn Wijarnpreecha3,4
1Division of Gastroenterology and Hepatology, Stanford University School of Medicine, Stanford, California, USA.
Alimentary pharmacology & therapeutics
|January 11, 2025
概括
脂肪性肝病 (SLD) 影响12.8%的瘦身美国成年人,与代谢功能障碍相关的SLD (MASLD) 是最常见的形式. 这凸显了即使在非肥胖个体中,也需要对肝脏疾病的认识和管理.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 胃肠病学 胃肠病学
- 公共卫生 公共卫生
背景情况:
- 脂肪性肝病 (SLD) 越来越被认可,但其在瘦人群中的患病率仍未得到充分研究.
- SLD的亚型,包括与代谢功能障碍相关的SLD (MASLD),与代谢功能障碍相关的和与酒精有关的SLD (MetALD) 和与酒精相关的肝病 (ALD),需要不同的流行病学评估.
- 了解瘦肉成年人中SLD患病率对于有针对性的公共卫生策略和临床管理至关重要.
研究的目的:
- 确定在美国成年人代表性人口中瘦肉性SLD及其特定亚型 (MASLD,MetALD,ALD) 的患病率.
- 为了评估肝纤维化的负担,包括晚期纤维化和肝硬化,在瘦肉的MASLD队列.
- 提供关于非肥胖个体肝病的最新流行病学数据.
主要方法:
- 分析了来自2017-2023年国家健康和营养检查调查 (NHANES) 2965名瘦身成年人 (≥18岁) 的数据.
- 对整体瘦肉SLD及其子类别的年龄调整的流行率计算.
- 在MASLD组内评估纤维化阶段 (显著,晚期,肝硬化).
主要成果:
- 瘦肉SLD的整体年龄调整后患病率为12.8%.
- 瘦身MASLD的流行率为9.3%,MetALD为1.3%,ALD为1.0%. 瘦身MASLD的流行率为9.3%,ALD的流行率为1.3%,ALD的流行率为1.0%.
- 在患有MASLD的瘦身成年人中,5.6%患有显著纤维化,2.4%患有晚期纤维化,2.0%患有肝硬化.
结论:
- 脂肪性肝病是一种严重的健康问题,影响了美国显著比例的瘦身成年人.
- MASLD是瘦个体中SLD的主要亚型,具有逐步肝损伤的风险.
- 这些发现强调了在瘦人群中对SLD进行查和早期干预的重要性,以预防晚期肝病.
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