英国和爱尔兰的症状性葡萄糖皮质激素诱导的上腺抑制:一项BPSU研究
Claire L Wood1,2, L C Lane2, H Barlow2
1Newcastle University Translational and Clinical Research Institute, Newcastle upon Tyne, UK claire.wood@ncl.ac.uk.
Archives of disease in childhood
|January 11, 2025
概括
在英国儿童中,葡萄糖皮质激素诱导的上腺抑制 (AS) 的发生率为每年10万分之一的0.09. 提高认识可能会减少病例,但关于预防AS的教育仍然至关重要.
科学领域:
- 儿科内分泌学 儿科内分泌学
- 药物监督 药物监督 药物监督
- 内分泌学 在内分泌学.
背景情况:
- 葡萄糖皮质类药物 (GCs) 广泛用于儿童,携带上腺抑制 (AS) 的风险.
- 意想不到的症状性GC诱导的AS和上腺危机需要小儿群体的仔细监测和管理.
- 了解GC诱导的AS的发生率和表现对于患者的安全至关重要.
研究的目的:
- 为了确定0-15岁儿童意外症状性葡萄糖皮质激素诱导的上腺抑制 (AS) 的发生率.
- 描述儿童患者GC诱导的AS的临床表现和管理策略.
- 将发现与国际研究进行比较,并为预防工作提供信息.
主要方法:
- 2020年9月至2022年9月使用英国儿科监测单位 (BPSU) 进行的前性监测研究.
- 纳入标准:症状的GC诱导的AS与生化证据或0-15岁儿童的上腺危机.
- 由儿科内分泌学团队收集的关于基本诊断,GC制剂,施用途径和管理的数据.
主要成果:
- 在25个月内收到190份报告,22例确诊病例 (18例AS,4例上腺危机).
- 在英国,每10万名儿童/年发生0.09例GC诱导的AS新病例的发病率.
- GCs通过口服,吸入和局部途径使用;7名患者接受了多种GC类型.
结论:
- 英国的GC诱导的AS发病率低于相似的加拿大研究.
- 英国儿科医生意识的提高可能有助于积极预防GC诱导的AS.
- 为家庭和医疗保健专业人员提供持续教育至关重要,以尽量减少与GC诱导的AS相关的发病率和死亡率.
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