在注射甲毒素A之前,化利多卡因作为麻醉剂. 一个随机试验
Meryam El Issaoui1,2, Marlene Elmelund3, Niels Klarskov1,2
1Department of Obstetrics and Gynecology, Herlev and Gentofte University Hospital, Herlev, Denmark.
BJU international
|January 11, 2025
概括
静脉内化利多卡因可显著降低过度活跃膀的本土毒素A (BTX-A) 注射期间的疼痛. 这种麻醉治疗改善了患者的舒适度,而没有增加不良事件,为泌尿科医生手术中的疼痛管理提供了更安全的替代方案.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 麻醉学 麻醉学
- 药理学 药理学是指药理学的学科.
背景情况:
- 过度活跃的膀 (OAB) 影响全球数以百万计的患者,通常通过内毒素A (BTX-A) 注射进行管理.
- 在BTX-A注射期间的手术疼痛可能是患者不适的重要来源,并可能影响治疗的坚持.
- 有效的疼痛管理策略对于改善OAB治疗期间的患者体验至关重要.
研究的目的:
- 评估静脉化利多卡因作为局部麻醉剂在注射BTX-A时减少手术疼痛的疗效.
- 为了比较疼痛评分,不良事件和性利多卡因和安慰剂治疗之间的患者满意度.
主要方法:
- 一个单中心,随机,双盲,安慰剂控制,两期交叉试验,涉及接受BTX-A注射的女性.
- 在交叉设计中,参与者在注射BTX-A之前,通过静脉注射接受了性利多卡因或安慰剂.
- 使用100毫米视觉模拟尺度 (VAS) 测量过程性疼痛;还记录了不良事件和患者满意度.
主要成果:
- 与安慰剂相比,静脉化的利多卡因显著降低了VAS疼痛平均得分 (21.3mm与41.6mm相比;P<0.001).
- 静脉神经系统评分的平均差异为-20.3毫米,表明化利多卡因可显著减轻疼痛.
- 治疗组之间的不良事件或患者满意度没有显著差异.
结论:
- 静脉内化利多卡因是一种有效的麻醉剂,可减轻与过活性膀的BTX-A注射相关的手术疼痛.
- 该治疗提供了有利的安全性,与安慰剂相比,不良事件没有增加.
- 化利多卡因代表了在BTX-A手术期间增强患者舒适度的有价值选择.
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