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通过H₂S气体介导的双重代谢途径的同步干扰/GOx用于增强瘤微波热疗法

Shimei Li^1,2, Qiong Wu¹, Zengzhen Chen¹

¹Key Laboratory of Cryogenics Science and Technology, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Laboratory of Controllable Preparation and Application of Nanomaterials, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing 100190, China.

ACS applied materials & interfaces

|January 11, 2025

概括

这项研究介绍了CAMGH,它是一种纳米平台,可以同时阻断瘤糖解和氧化酸化 (OXPHOS),从而耗尽能量并抑制生长. 这种方法通过克服瘤自我修复机制来增强微波热疗法.

科学领域:

生物医学工程生物医学工程
纳米技术纳米技术
癌症治疗癌症治疗

背景情况:

亚致命瘤细胞表现出代谢可塑性,在糖解和氧化酸化 (OXPHOS) 之间切换能量. 针对这两种途径对于有效抑制瘤生长至关重要.
微波 (MW) 热疗法可以诱导瘤损伤,但通常受到瘤自我修复机制的限制.

研究的目的:

开发一种多功能纳米平台 (CAMGH),能够同步干扰亚致命瘤中的糖解和OXPHOS.
通过克服瘤对热和亡的抵抗力来提高MW热疗法的疗效.

主要方法:

一个基于Co-MOF的纳米平台 (CAMGH) 进行了工程设计,结合了anethole trithione (ADT), myristyl alcohol (MA),葡萄糖氧化酶 (GOx) 和氨酸 (HA).
在CAMGH与低功率MW照射一起使用,以准瘤代谢.
纳米平台对腺三酸盐 (ATP) 水平,热冲击蛋白90 (HSP90) 和caspase-3激活的影响进行了评估.

主要成果:

通过GOx诱导的葡萄糖消耗,CAMGH有效地阻断了糖解,并通过活性氧物种 (ROS) 和硫化 (H2S) 的协同作用抑制了OXPHOS.
这种双重的代谢阻塞导致了显著的ATP耗尽,抑制HSP90和激活caspase-3.
结合疗法证明增强了瘤抑制和逆转热和亡抵抗.

结论:

CAMGH纳米平台为瘤中双重代谢途径的同步干扰提供了一种新的策略.
这种方法显示出克服瘤自我修复机制的潜力,并改善MW热疗法的治疗结果.

关键词:

奥克斯福斯 (OXPHOS) 是一个通过双重代谢途径.葡萄糖溶解是什么微波热疗法是一种微波热疗法.同时的干扰是同步的干扰.

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