阿米奥达龙诱导的甲状腺功能障碍的发生率和危险因素:全国性的回顾性队列研究
Seo Young Sohn1, Yun Jin Kim2,3, Sungsoo Cho4
1Division of Endocrinology and Metabolism, Department of Internal Medicine, Myongji Hospital, Hanyang University College of Medicine, Goyang, Republic of Korea.
在充足的地区,阿米奥达龙诱导的甲状腺功能低下症比铁毒性更频繁. 阿米奥达龙诱导的甲状腺功能障碍的主要危险因素包括慢性脏病和哈希莫托病.
科学领域:
- 内分泌学 在内分泌学.
- 心脏病学 心脏病学
- 药理学 药理学是指药理学的学科.
背景情况:
- 阿米奥达龙是一种强效的抗心律失常药物.
- 甲状腺功能障碍是阿米奥达龙治疗的常见副作用.
- 了解发病率和风险因素至关重要,特别是在充足的地区.
研究的目的:
- 为了确定阿米奥达龙诱导的甲状腺毒性病 (AIT) 和阿米奥达龙诱导的甲状腺功能低下 (AIH) 的发生率.
- 确定与AIT和AIH相关的独立风险因素.
- 为在不同患者群体中管理amiodarone治疗提供见解.
主要方法:
- 使用韩国国家医疗保险数据库进行回顾性队列研究.
- 包括27,023名因心律失常而接受阿米奥达龙治疗的患者.
- 考克斯回归分析以确定甲状腺功能障碍的独立风险因素.
主要成果:
- 在平均6.4年的随访期间,4.9%的人患上了甲状腺毒性病,11.5%的人患上了甲状腺功能低下症.
- 发生率为AIT每1000人年6.92%,AIH每1000人年17.1%.
- 对AIT的危险因素包括慢性病 (CKD) 和哈希莫托的甲状腺炎. AIH与女性性别,糖尿病,CKD和哈西莫托的甲状腺炎有关.
结论:
- 在充足的地区,阿米奥达龙诱导的甲状腺功能低下 (AIH) 比阿米奥达龙诱导的甲状腺毒性 (AIT) 更为普遍.
- 特定的风险因素,如CKD,哈西莫托甲状腺炎,女性性别和糖尿病增加了发展AIT或AIH的可能性.
- 建议定期监测甲状腺功能的阿米奥达龙患者,特别是那些具有已确定的风险因素的患者.
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