接种疫苗的结核病患者中存在SARS-CoV-2感染和不良结果的风险
Renin Chang1, Sheng-Yin Chen2, Tina Yi-Jin Hsieh3
1Department of Medical Education and Research, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan; Department of Recreation and Sports Management, Tajen University, Pintung, Taiwan; School of Medicine, Chung Shan Medical University, Taichung, Taiwan.
结核病 (TB) 患者在接种疫苗后面临突破性COVID-19感染和严重结果的更高风险. 加强警和优先接种疫苗对于这个脆弱的人群至关重要.
科学领域:
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
- 肺部病理学 肺部病理学
背景情况:
- 关于突破性严重急性呼吸系统综合征冠状病毒2 (SARS-CoV-2) 感染,医疗利用和结核病 (TB) 患者死亡率的数据有限.
- 了解这些风险对于在结核病患者中管理COVID-19至关重要,因为结核病患者可能面临更高的不良结果风险.
研究的目的:
- 与非结核病患者相比,评估COVID-19突破性感染和结核病患者严重结局的风险.
- 检查结核病患者在SARS-CoV-2感染后的医疗利用,包括急诊室访问和重症监护入院.
主要方法:
- 一项回顾性研究利用美国电子医疗记录从2020年1月到2022年3月.
- 确定了15541名结核病患者和15541名匹配的非结核病对照,所有人都接种了初级系列疫苗,并且没有以前的COVID-19.
- 在接种疫苗后的365天内进行了随访,分析了突破性感染和严重的结果 (住院治疗,机械呼吸,ICU入院,住院死亡率).
主要成果:
- 结核病患者出现突破性SARS-CoV-2感染的风险明显更高 (调整后的危险比率[aHR],1.444).
- 结核病患者还显示急诊室访问 (aHR, 1.244) 和重症监护入院 (aHR, 1.404) 的风险增加.
- 这些趋势在根据年龄,性别和结核病状况分层的子组分析中持续存在.
结论:
- 结核病患者患有COVID-19突破性感染和不良结果的风险增加.
- 医疗保健提供者应对结核病患者保持高度警,以便对COVID-19保持警.
- 对于结核病患者,建议优先进行COVID-19疫苗接种和持续监测.
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