肉类摄入量与肠道微生物群的组成和功能有关
Susanna C Larsson1, Ulrika Ericson2, Koen F Dekkers3
1Medical Epidemiology, Department of Surgical Sciences, Uppsala University, Sweden; Unit of Cardiovascular and Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
Clinical nutrition (Edinburgh, Scotland)
|January 11, 2025
概括
加工红肉的摄入量显著改变了肠道微生物组合和功能,影响了许多健康生物标志物. 这项大型研究强调了肉类.
科学领域:
- 微生物组研究的研究.
- 营养科学 营养科学
- 人类健康 人类健康 人类健康
背景情况:
- 肉类消费与慢性疾病有关.
- 肠道微生物组的组成可能受到饮食的影响.
- 了解肉类与微生物群之间的相互作用对于公共卫生至关重要.
研究的目的:
- 为了识别与肉类摄入相关的肠道微生物组特征.
- 调查肉类消费与宿主因素之间的联系.
- 探索不同类型的肉类对肠道微生物群的影响.
主要方法:
- 在9669个个体中对肠道微生物群进行深度猎枪元基因组学测序.
- 食物频率问卷以评估白色,未加工的红色和加工的红肉的摄入量.
- 使用线性回归来测试与微生物多样性,丰富性,基因功能和宿主生物标志物的关联的统计分析.
主要成果:
- 加工红肉摄入量与减少的alpha微生物多样性相关.
- 肉类摄入与特定的肠道微生物物种和途径 (例如,氨基酸降解) 相关.
- 在加工红肉,微生物代谢物 (如TMAO,肌酸) 和临床生物标志物 (如胰岛素,葡萄糖,甘油三) 之间观察到的关联.
结论:
- 肉类摄入量,特别是加工的红肉,显著改变了肠道微生物群的组成和功能能力.
- 这些修改与与健康相关的生物标志物的变化有关.
- 这些发现表明,通过肠道微生物组,加工肉类消费与慢性疾病风险之间存在潜在的联系机制.
相关概念视频
Anatomy of the Intestines
71.3K
Although digestion of proteins, carbohydrates, and lipids may begin in the stomach, it is completed in the intestine. The absorption of nutrients, water, and electrolytes from food and drink also occurs in the intestine. The intestines can be divided into two structurally distinct organs—the small and large intestines.
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...
71.3K
Bacterial Flora of the Large Intestine
377
The gut microbiome is formed by a vast and diverse community of bacteria that colonizes our large intestine. These bacteria start residing in the gut from birth and continue diversifying throughout life, influenced by factors such as diet, lifestyle, and stress. The gut bacterial community also includes bacteria from food and those that enter the colon through the anus.
The normal gut flora of the colon plays a critical role in generating essential vitamins such as vitamins K, B5, and B7.
The normal gut flora of the colon plays a critical role in generating essential vitamins such as vitamins K, B5, and B7.
377
What is Monogastric Digestion?
70.5K
The human body contains a monogastric digestive system. In a monogastric digestive system, the stomach only contains one chamber in which it digests food. Several other animal species also have monogastric digestive systems, including pigs, horses, dogs, and birds. This chapter, however, focuses on the human digestive system.
70.5K
Microorganisms in Agriculture and Food industry
Microorganisms play a crucial role in agriculture and the food industry, contributing to soil fertility, crop protection, and food production. Their functions range from nitrogen fixation and biopesticide production to fermentation and food preservation, making them indispensable to sustainable farming and food safety.Role in AgricultureNitrogen-fixing bacteria, such as Rhizobium (symbiotic) and Azotobacter (free-living), convert atmospheric nitrogen into ammonia through biological nitrogen...


