非酒精性脂肪肝病与脆弱性之间的关系:系统性审查和元分析
Shaghayegh Khanmohammadi1, Mahdi Masrour2, Parisa Fallahtafti3
1School of Medicine, Tehran University of Medical Sciences, Tehran, Iran; Research Center for Immunodeficiencies, Pediatrics Center of Excellence, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran; Non-Communicable Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.
Diabetes & metabolic syndrome
|January 11, 2025
概括
在非酒精性脂肪性肝病 (NAFLD) 中,脆弱性很常见,个体患有脆弱性的几率超过两倍. 早期评估NAFLD患者的脆弱性可以指导管理和改善健康结果.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 老年病的医生 老年病的医生
- 内部医学 内部医学
背景情况:
- 脆弱性在末期肝病中普遍存在,但其在非酒精性脂肪肝疾病 (NAFLD) 中的作用尚不清楚.
- 非酒精性脂肪性肝病 (NAFLD) 影响着相当一部分人口,了解诸如虚弱等相关疾病对于全面的患者护理至关重要.
研究的目的:
- 系统地审查和分析NAFLD患者虚弱的相关性和患病率.
- 量化诊断为NAFLD的个体虚弱的风险增加.
主要方法:
- 对主要科学数据库 (PubMed/MEDLINE,EMBASE,Web of Science,Scopus) 进行了全面的系统审查.
- 使用随机效应模型进行元分析,以确定NAFLD脆弱性的聚合流行率和几率比率.
- 包括18项研究,包括3673名参与者,以评估脆弱度指标,如握力和平衡时间.
主要成果:
- 在NAFLD患者中,脆弱的概率比率为2.03,与对照人群相比,概率是两倍以上.
- 在NAFLD中,虚弱的综合流行率是23%,使用肝脏虚弱指数 (LFI) 和8%使用虚弱指数 (FFI).
- 报告了平均握力 (26.4公斤) 和平衡时间 (23秒),在NAFLD队列中的肝硬化患者中观察到较低的握力.
结论:
- 在患有NAFLD的个体中,脆弱性非常普遍,远远高于一般人群.
- NAFLD独立地与明显增加的虚弱风险有关.
- 建议对NAFLD患者的脆弱性进行例行评估,以便及时进行有针对性的干预,并改善临床结果.
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