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通过CRISPR/(WAe009-A-2K) Cas9编辑生成一个PDK-1淘汰人类胚胎干细胞系

Amina Saleem1, Mingyu Wei2, Muhammad Khawar Abbas3

  • 1Anzhen Hospital, Capital Medical University, Beijing 100029, China; Beijing Institute of Heart, Lung, and Blood Vessel Diseases, Beijing 100029, China.

Stem cell research
|January 11, 2025
PubMed
概括

研究人员创建了一个淘汰赛的人类胚胎干细胞系,缺乏Pyruvate Dehydrogenase Kinase1 (PDK1). 这个PDK1-KO hESC线是研究PDK1的一个有价值的工具.

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CRISPR01:59

CRISPR

Genome editing technologies allow scientists to modify an organism’s DNA via the addition, removal, or rearrangement of genetic material at specific genomic locations. These types of techniques could potentially be used to cure genetic disorders such as hemophilia and sickle cell anemia. One popular and widely used DNA-editing research tool that could lead to safe and effective cures for genetic disorders is the CRISPR-Cas9 system. CRISPR-Cas9 stands for Clustered Regularly Interspaced...
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