在患有或没有精神病症状的儿科双相情感障碍患者中,皮层下结构体积的变化
Weijia Gao1, Qingli Mu2, Dong Cui3
1Department of Child Psychology, The Children's Hospital, National Clinical Research Center for Child Health, Zhejiang University School of Medicine, National Children's Regional Medical Center, Hangzhou, Zhejiang, China.
患有精神病症状的儿科双极性障碍 (PBD) 显示横向和第三心室扩大. 侧室可能有助于区分精神病性PBD与非精神病性PBD,表明潜在的神经生物学差异.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 神经成像是一种神经成像.
背景情况:
- 患有精神病症状的儿科双极性障碍 (PBD) 与严重的社会功能障碍有关.
- 带有精神病症状的PBD的潜在生物机制尚不清楚.
- 调查皮层下结构体积变化对于理解PBD至关重要.
研究的目的:
- 为了调查儿科双相情感障碍 (PBD) 带有和没有精神病症状的皮下结构体积差异.
- 确定潜在的神经成像生物标志物,以区分精神病和非精神病性PBD.
主要方法:
- 招募了24名精神病性PBD (P-PBD),24名非精神病性PBD (NP-PBD) 患者和18名健康对照 (HC).
- 使用3.0 T MRI扫描和FreeSurfer软件进行皮质下体积分析.
- 采用ANCOVA,部分相关性和ROC分析来比较群体并确定生物标志物.
主要成果:
- 在双侧心室,第三心室,左丘脑和右腹中观察到显著的体积差异.
- PBD患者的第三心室体积增加;P-PBD患者的双边侧心室比HCs扩大.
- 左侧心室体积最好区分P-PBD与NP-PBD;第三室最好区分PBD与HCs.
结论:
- 带有精神病症状的PBD与更广泛的横向和第三腹腔扩大有关.
- 双边侧腔室显示出作为分辨P-PBD和NP-PBD的神经生物标志物的潜力.
- 结构性大脑变化可能是PBD独特的临床表现的基础.
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