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Updated: Jun 3, 2025

Pooled shRNA Screen for Reactivation of MeCP2 on the Inactive X Chromosome
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单细胞RNA-seq识别了延长的小鼠生殖系X染色体重激活动态,由PRC2-依赖机制指导

Yaqiong Liu1, Xianzhong Lau2, Prabhakaran Munusamy2

  • 1King's College London, Centre for Gene Therapy and Regenerative Medicine, School of Basic & Medical Biosciences, Faculty of Life Sciences and Medicine, London, UK.

Developmental cell
|January 11, 2025
PubMed
概括

女生殖细胞在发育过程中重新激活其沉默的X染色体. 这项研究追踪了X染色体活性化 (XCR) 动态,将其与表观遗传记忆和女性半转化联系起来.

关键词:
在 PRC2 中,PRC2 是 PRC2 的第一个类型.X染色体的重新激活过程一个等位基因的特定表达.剂量补偿剂量补偿剂量补偿全基因组的重编程.胚胎细胞是一种生殖细胞.一个单细胞RNA-seqq.

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