提高高灵敏度C反应蛋白和腹腔大动脉动脉瘤的风险:挪威HUNT研究中的前性基于人口的研究
Aslak Bryne Håland1, Erney Mattsson2, Vibeke Videm3
1Department of Vascular Surgery, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway; Department of Circulation and Medical Imaging, Faculty of Medicine and Health Sciences, NTNU-Norwegian University of Science and Technology, Trondheim, Norway.
概括
提高高灵敏度C反应蛋白 (hs-CRP) 显著增加患腹腔大动脉动脉瘤 (AAA) 的风险. 这项前性研究发现,较高的hs-CRP水平与AAA诊断的可能性更高相关.
科学领域:
- 心血管科学 心血管科学
- 炎症研究 炎症研究
- 流行病学 流行病学
背景情况:
- 炎症在腹腔大动脉动脉瘤 (AAA) 发病过程中起着关键作用.
- 之前的研究表明,炎症生物标志物,如高灵敏度C反应蛋白 (hs-CRP) 和AAA之间存在联系.
- 调查这种关联的前性研究有限.
研究的目的:
- 研究hs-CRP水平升高与发展AAA的风险之间的关联.
- 使用前性,基于人口的队列设计进行可靠的分析.
- 确定hs-CRP是否可以作为AAA风险的预测生物标志物.
主要方法:
- 一项基于人口的前性队列研究,涉及来自特伦德拉格健康研究 (HUNT) 的46,322名参与者.
- 平均随访时间为12.6年,期间记录了407例AAA诊断.
- 考克斯比例危险回归被用来分析hs-CRP (连续和分类) 和AAA风险之间的关联,以多个共变量进行调整.
主要成果:
- hs-CRP的1 mg/L增加与AAA风险增加2%有关 (调整后HR为1.02).
- 具有hs-CRP≥2 mg/L的个体几乎是AAA风险的两倍 (调整后HR为1.84).
- 随着hs-CRP四分位数的增加,风险逐渐增加,最高四分位数的风险增加了近四倍 (调整后的HR 3.87).
结论:
- 升高的hs-CRP水平与患腹腔大动脉动脉瘤的风险增加有显著的关联.
- hs-CRP显示出作为AAA有价值的预测生物标志物的潜力.
- 这些发现强调了炎症在AAA发展中的重要性.
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