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暴露于/同载体抑制剂和甲状腺功能的标记物之间的关联:系统性审查和元分析
Hyuna Jang1, Luke Calder1, Jeong Weon Choi1
1Department of Environmental Science, Baylor University, Waco, TX, USA.
暴露于甲酸盐,酸盐和硫酸盐 (NIS抑制剂) 与甲状腺功能的改变有关. 这一审查证实了NIS抑制剂与人类甲状腺刺激激素 (TSH) 之间的积极关联.
科学领域:
- 内分泌学 在内分泌学.
- 环境健康 环境健康
- 毒理学 毒理学 毒理学
背景情况:
- 甲酸盐,酸盐和硫酸酸盐是已知的/化同载体 (NIS) 抑制剂.
- 这些NIS抑制剂可以破坏甲状腺中酸的吸收,从而可能影响甲状腺功能.
- 总结NIS抑制剂暴露与甲状腺功能之间的关联的人类数据有限.
研究的目的:
- 系统地审查和总结暴露在人体内的甲酸盐,酸盐和硫酸盐和甲状腺功能标志物之间的关联.
- 为了确定关键的知识差距,为未来的研究NIS抑制剂暴露和甲状腺健康.
主要方法:
- 在四个数据库 (Embase,Web of Science,PubMed,CINAHL plus) 进行了系统的文献搜索,截至2024年5月31日.
- 包括检查NIS抑制剂水平与甲状腺激素 (FT4,TT4,FT3,TT3) 和TSH之间的关系的研究.
- 进行了一项随机效应元分析,以估计聚合效应大小.
主要成果:
- 从2588项已识别的研究中,将4项研究纳入了元分析.
- 甲状腺刺激激素 (TSH) 水平与联合的NIS抑制剂 (β:0.105) 和酸盐 (β:0.133) 有积极的关联.
- 在NIS抑制剂和自由三甲状腺素 (FT3) 和总甲状腺素 (TT4) 之间观察到负面趋势,尽管有些不具有统计学意义.
结论:
- 这项研究为NIS抑制剂暴露与人类甲状腺功能标志物之间的关联提供了全面的证据.
- 这些发现与已知NIS抑制的体内机制一致.
- 需要进一步的研究才能充分阐明这些复杂的关系.
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