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通过饮食摄入的PCDD/F估计水平与人类精子质量之间的关联

María Ángeles Martínez¹, Albert Salas-Huetos², María Fernández de la Puente³

¹Institut d'Investigació Sanitària Pere Virgili (IISPV), Reus, Spain; Universitat Rovira i Virgili, Departament de Bioquímica i Biotecnologia, Alimentaciò, Nutrició, Desenvolupament i Salut Mental ANUT-DSM, Reus, Spain; Centro de Investigación Biomédica en Red Fisiopatología de la Obesidad y la Nutrición (CIBEROBN), Institute of Health Carlos III, Madrid, Spain; Department of Pharmacology, therapeutics and Toxicology, Faculty of veterinary. Universitat Autònoma de Barcelona, Cerdanyola del Vallès 08193, Catalonia, Spain.

Reproductive toxicology (Elmsford, N.Y.)

|January 11, 2025

概括

饮食中较高的二氧化和 furan (PCDD/F) 摄入量与男性的精子头异常增加有关. 这一发现表明,食品中的环境污染物对男性生殖健康存在潜在风险.

科学领域:

环境健康环境健康
生殖毒理学生殖毒理学
人类营养人类营养

背景情况:

多二二二氧化物 (PCDD) 和多二二二 (PCDF),统称为二氧化物类化合物,是环境和食品中发现的持久性有机污染物.
暴露于PCDD/F与各种不良健康影响有关,但它们对人类精子质量的影响仍未得到充分研究.
了解饮食PCDD/F暴露与男性生育能力之间的关系对于公共卫生评估至关重要.

研究的目的:

调查估计PCDD/Fs饮食摄入量与人类精子质量参数之间的关联.
评估饮食中的二氧化和暴露对男性生殖健康指标的潜在影响.

主要方法:

从Led-Fertyl研究中对200名年龄在18-40岁的男性进行了截面研究.
使用食品频率问卷和食品污染物数据估计的PCDD/Fs的饮食摄入量,主要来自西班牙来源.
我们使用线性回归模型来分析关联,并根据潜在的混因素进行调整.

主要成果:

饮食中PCDD/F摄入量最高的参与者显示精子头异常的百分比明显更高 (p趋势=0.037).
在增加能量调整后的PCDD/Fs总饮食摄入量和精子头异常之间观察到积极的关联.
对于其他精子质量参数,没有发现显著的关联.

结论:

饮食中摄入较高的PCDD/Fs与男性精子头异常的百分比增加显著相关.
这些发现表明,通过饮食接触二氧化和 furan 可能会对人类精子质量产生负面影响,并可能损害生殖健康.
需要进一步的研究来阐明PCDD/F对男性生育能力的影响的机制和程度.

关键词:

内分泌干扰化学物质 (EDCs) 的使用聚化二子-p- furan (PCDD/Fs) 是一种多化合物.精子质量精子质量食物摄入量食物摄入量不孕不育不孕不育不孕不育

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