针对结肠癌治疗的基于多糖的药物输送有针对性的方法:综合性审查
Hua Shao1, Minghua Liu2, Hongfang Jiang3
1Department of General Surgery, Shengjing Hospital of China Medical University, Shenyang 110000, Liaoning, China.
International journal of biological macromolecules
|January 11, 2025
概括
基于多糖的结肠向药物递送系统 (CDDS) 对结肠癌治疗有望. 这些系统提高药物特异性,减少副作用,并通过利用天然聚合物进行局部传递来提高治疗结果.
科学领域:
- 在瘤学瘤学.
- 生物材料科学 生物材料科学
- 药物输送系统 药物输送系统
背景情况:
- 结肠癌对全球健康造成重大负担,目前的治疗方法面临系统毒性和低效率等局限性.
- 结肠癌的传统疗法往往导致不良副作用和瘤部位的药物度低于最佳水平.
- 针对结肠的药物递送系统 (CDDS) 正在探索,通过利用结肠的生理特征进行局部药物释放来克服这些局限性.
研究的目的:
- 审查最近基于多糖的结肠向药物递送系统 (CDDS) 在结肠癌治疗中的进展.
- 评估用于结肠癌的CDDS中使用天然聚合物的机制,治疗潜力和挑战.
- 突出这些系统在提高药物特异性和减少全身毒性的有效性.
主要方法:
- 对基于多糖的CDDS用于结肠癌治疗的当前文献的综述.
- 对药物释放机制,配方策略 (纳米粒子,微球) 和体外/体外研究的分析.
- 评估CDDS对结肠癌细胞亡,生物可用性和细胞毒性的影响.
主要成果:
- 基于多糖的CDDS证明了有效的局部特异性药物输送到结肠,利用诸如奇托,pectin和alginate等聚合物.
- 这些系统增强结肠癌细胞亡和细胞毒性,同时最大限度地减少全身副作用并改善患者的服从性.
- 纳米颗粒和微球等配方在临床前研究中显示了改善的生物可用性和有针对性的交付.
结论:
- 基于多糖的CDDS代表了提高结肠癌治疗效率和患者结果的有希望的策略.
- 需要进一步的研究来解决与胃肠道过渡和pH变异性相关的挑战,以实现最佳的临床转化.
- 这些创新的药物输送系统为更有针对性,更有效,更以患者为中心的结肠癌护理提供了途径.
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