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在老鼠大脑中神经解剖学的左右大脑宽度不对称

Andrew Silberfeld¹, James M Roe², Jacob Ellegood³

¹Department of Genetics, Harvard Medical School, Boston, MA, USA; Department of Pathology, Brigham and Women's Hospital, Boston, MA, USA.

|January 11, 2025

概括

研究人员在小鼠中发现了解剖学大脑不对称性,揭示了前后体积差异的前后模式. 这一发现为了解人类大脑的不对称性提供了基础,这是一个知识有限的复杂领域.

科学领域:

神经科学是一个神经科学.
比较解剖学的比较解剖学
脑部成像脑部成像

背景情况:

人类大脑表现出广泛的左右解剖学和功能不对称.
对解剖学不对称性的微观理解是有限的,只有少数已建立的动物模型.
人类大脑表现出微妙的区域不对称性和宏观规模的扭曲 (大脑花).

研究的目的:

为了研究小鼠神经解剖学不对称的存在和模式.
建立一个小鼠模型来研究大脑不对称的机制.
将老鼠大脑的不对称性与人类模式和已知的功能不对称性进行比较.

主要方法:

利用了来自六个小鼠队伍 (大约3,500只动物) 的神经成像数据.
分析了大脑区域体积,表面积和位置不对称性的模式.
包括已知的男女大脑差异作为积极对照.

主要成果:

确定了一个前后体积不对称的模式:前部区域在右侧更大,后部区域在左侧更大.
在表面积和位置不对称性中观察到类似的趋势,这表明整个大脑的扭曲模式类似于人类大脑花.
在小鼠身上,没有发现解剖不对称性和已知的功能不对称性之间有明确的关系.

结论:

在小鼠中建立了解剖学大脑不对称的签名,提供了一个有价值的模型.
突出了大脑不对称性中的结构功能关系的复杂性.
奠定了未来研究人类大脑不对称的机制基础的基础.

关键词:

不对称的不对称性脑子脑子脑子脑子半球半球是地球半球.横向性横向性横向性侧面化是一种侧面化.左-右,左-右,这是一个很好的方法.鼠标鼠标是一个鼠标.

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