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顺序与连续养及其对重症患者肠道微生物群的影响:一项随机对照试验

Bo Yao¹, Jian-Yu Liu², Ying Liu³

¹Department of Critical Care Medicine, Qilu Hospital (Qingdao), Cheeloo College of Medicine, Shandong University, 758 Hefei Road, Qingdao, Shandong, 266035, China; Department of Critical Care Medicine, The Affiliated Hospital of Qingdao University, 1677 Wutaishan Road, Qingdao, Shandong, 266000, China.

Clinical nutrition ESPEN

|January 11, 2025

概括

顺序养 (SF) 在重症患者中没有增加肠道微生物群的多样性,但改变了微生物的丰度和代谢物. 安全性和肠道耐受性与连续养 (CF) 相当.

科学领域:

关键护理医学关键护理医学
胃肠病学胃肠病学
微生物组研究的研究.

背景情况:

肠道微生物群失调与危急疾病的严重程度和多器官功能障碍综合征有关.
以前的研究表明,与连续养 (CF) 相比,顺序养 (SF) 的肠道微生物群α多样性趋势更高.
这项研究旨在在重症患者中证实这些发现.

研究的目的:

研究连续养 (SF) 与连续养 (CF) 对严重病患者肠道微生物群多样性和组成的影响.
分析相关的代谢概况和临床结果.
与CF相比,评估SF的安全性和耐受性.

主要方法:

一项非盲目的随机对照研究,涉及重病患者.
患者最初接受连续养,然后随机分配到SF (间歇性) 或CF.
收集便和血清样本进行16S rRNA基因测序和非向代谢;监测临床指标.

主要成果:

在SF和CF组之间,肠道微生物群α-多样性 (香农指数) 没有显著差异.
SF改变了特定肠道微生物 (Erysipelotrichaceae_UCG-003,Howardella) 的丰富性,并影响了代谢指标,如白蛋白,总胆固醇和总胆汁酸水平.
确定了58种不同丰富的代谢物,主要胆酸生物合成是显著丰富的途径.

结论:

顺序养 (SF) 在重症患者中不会增强肠道微生物群的多样性,但会改变微生物组成和代谢物概况.
这些变化的临床意义需要进一步研究.
与CF相比,SF表现出类似的肠道耐受性和安全性.

关键词:

不断的养不断的养我们的肠道微生物群.在重症监护病房的重症监护病房.顺序的养顺序的养

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