"偷偷"的非炎症性食道候群病:形态线索和与与炎症相关的候群病的比较
Yasamin Mirzabeigi1, Turky Alkhatery2, Amr Abulaban3
1Department of Pathology and Laboratory Medicine, University of Miami Miller School of Medicine, Miami, Florida, USA yasamin.mirzabeigi@jhsmiami.org.
Journal of clinical pathology
|January 11, 2025
概括
坎迪达食管炎可以在没有炎症的情况下出现,表现出状近皮炎症,特别是在吸烟者中. 这一发现对于某些患者群体的准确诊断至关重要.
科学领域:
- 胃肠病学 胃肠病学
- 病理学 病理学 病理学
- 传染性疾病 传染性疾病
背景情况:
- 坎迪达食道炎通常通过H&E污点的急性炎症来识别.
- 然而,有些病例缺乏炎症,需要通过有"片状"外观的帕拉基拉托斯识别生物体.
研究的目的:
- 为了将Candida食道炎的组织形态学模式与临床概况相关联.
- 为了调查与未发炎的Candida食道炎相关的因素.
主要方法:
- 审查了来自患有Candida食道炎的患者的53个活检样本.
- 评估了急性炎症,淋巴细胞瘤和淋巴结合物的活检.
- 与临床数据相关联的组织形态学,包括吸烟状态和免疫状态.
主要成果:
- 在53例活检中,有20例缺乏急性炎症;33例有急性炎症.
- 吸烟者显著更有可能出现近性瘤,并且缺乏急性中性友浸 (p=0.025).
- 没有其他临床因素与炎症模式相关.
结论:
- 坎迪达食管炎可能是无炎症的,呈现出"薄片"的帕拉基拉托斯症,或表现出急性炎症/淋巴细胞症.
- 吸烟者经常没有炎症,这表明局部免疫抑制作用.
- 组织形态学变异对于诊断Candida食道炎很重要,特别是在吸烟者中.
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