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Updated: Jun 3, 2025

Identification of Alternative Splicing and Polyadenylation in RNA-seq Data
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使用spvAPAPA对来自单细胞和空间转录组学数据的替代多基化进行监督分析.

Qinglong Zhang1, Liping Kang1, Haoran Yang1

  • 1Cancer Institute, Suzhou Medical College, Soochow University, NO. 199 Ren-ai Road, SIP, Suzhou 215000, China.

Briefings in bioinformatics
|January 11, 2025
PubMed
概括

本研究介绍了spvAPA,这是一个新的监督框架,用于分析单细胞和空间转录组学中的替代多基化 (APA). 它通过整合基因表达和APA数据来帮助发现细胞亚群.

关键词:
替代性的多基化.一个单细胞RNA-seqq.空间转录学 空间转录学监督分析 监督分析视觉化的可视化

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Alternative RNA Splicing02:18

Alternative RNA Splicing

Alternative RNA splicing is the regulated splicing of exons and introns to produce different mature mRNAs from a single pre-mRNA. Unlike in constitutive splicing where a single gene produces a single type of mRNA, alternative splicing allows an organism to produce multiple proteins from a single gene and plays an important role in protein diversity.
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Splicing is the process by which eukaryotic RNA is edited before its translation into protein. The RNA strand transcribed from eukaryotic DNA is called the primary transcript. The primary transcripts that become mRNAs are called precursor messenger RNAs (pre-mRNAs). Eukaryotic pre-mRNA contains alternating sequences of exons and introns. Exons are nucleotide sequences that code for proteins, whereas introns are the non-coding regions. In RNA splicing, introns are removed and exons are bonded...
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